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AB156342

Recombinant Human MRPL1 protein (His tag N-Terminus)

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Recombinant Human MRPL1 protein (His tag N-Terminus) is a Human Full Length protein, in the 51 to 325 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

BM-022, MRPL1, Large ribosomal subunit protein uL1m, L1mt, MRP-L1

1 Images
SDS-PAGE - Recombinant Human MRPL1 protein (His tag N-Terminus) (AB156342)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human MRPL1 protein (His tag N-Terminus) (AB156342)

15% SDS-PAGE analysis of 3µg ab156342.

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9BYD6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSKKTKKGAKEKTPDEKKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKAVHLLKKFQILDFTSPKQSVYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEINKVAVFTENASEVKIAEENGAAFAGGTSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKYPKLSRNSIGRDIPKMLELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVINEVCRHRPLNLGPFVVRAFLRSSTSEGLLLKIDPLLPKEVKNEESEKEDA","proteinLength":"Full Length","predictedMolecularWeight":"33.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":325,"aminoAcidStart":51,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BYD6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MRPL1 protein also known as Mitochondrial Ribosomal Protein L1 is an essential component of the mitochondrial ribosome. It weighs approximately 34.1 kDa and plays a critical mechanical role in the synthesis of proteins within mitochondria. MRPL1 is expressed in various tissues with high metabolic activity particularly in the liver muscle and brain reflecting its importance in these energy-demanding areas.
Biological function summary

MRPL1 contributes to mitochondrial protein synthesis by being part of the mitochondrial large ribosomal subunit. It is one of the components that build the ribosome's structure enabling the translation of mitochondrial-encoded proteins. This integration into the ribosomal complex facilitates the accurate translation of mRNA which is necessary for proper mitochondrial function and energy production.

Pathways

MRPL1 functions in pathways related to mitochondrial translation and energy metabolism. It plays a part in the mitochondrial translation pathway a critical component for cellular energy production through oxidative phosphorylation. This pathway largely involves interactions with proteins such as MRPS22 which is part of the small subunit aiding in the synthesis of proteins important for the electron transport chain.

Altered MRPL1 function is associated with mitochondrial diseases and metabolic disorders. Mutations or defects in MRPL1 can lead to conditions like cardiomyopathy and MELAS syndrome (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes). In these diseases the relationship between MRPL1 and the malfunctioning of mitochondrial-encoded proteins is evident and it interacts with other mRNAs translated in mitochondria impacting cellular energy balance.
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Specifications

Form

Liquid

Additional notes

ab156342 is purified using conventional chromatography techniques.

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General info

Sequence similarities

Belongs to the universal ribosomal protein uL1 family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

See full target information MRPL1
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