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AB137164

Recombinant Human MRPL28 protein (His tag N-Terminus)

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Recombinant Human MRPL28 protein (His tag N-Terminus) is a Human Full Length protein, in the 56 to 256 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MAAT1, MRPL28, Large ribosomal subunit protein bL28m, Melanoma antigen p15, Melanoma-associated antigen recognized by T-lymphocytes, L28mt, MRP-L28

1 Images
SDS-PAGE - Recombinant Human MRPL28 protein (His tag N-Terminus) (AB137164)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MRPL28 protein (His tag N-Terminus) (AB137164)

15% SDS-PAGE analysis of ab137164 (3μg)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q13084

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8.5 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMNGQRERVEDVPIPIYFPPESQRGLWGGEGWILGQIYANNDKLSKRLKKVWKPQLFEREFYSEILDKKFTVTVTMRTLDLIDEAYGLDFYILKTPKEDLCSKFGMDLKRGMLLRLARQDPQLHPEDPERRAAIYDKYKEFAIPEEEAEWVGLTLEEAIEKQRLLEEKDPVPLFKIYVAELIQQLQQQALSEPAVVQKRASGQ","proteinLength":"Full Length","predictedMolecularWeight":"25.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":256,"aminoAcidStart":56,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q13084","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPL28 also known as Mitochondrial Ribosomal Protein L28 is a component of the mitochondrial ribosome. It plays a critical role in protein synthesis within mitochondria. The protein has a molecular mass of about 32 kDa. MRPL28 is expressed in many tissues with higher expression levels observed in tissues with high energy demands such as the heart muscles and liver.
Biological function summary

MRPL28 integrates into the large subunit of the mitochondrial ribosome forming part of the machinery required for mitochondrial protein synthesis. This protein is essential for the production of proteins encoded by mitochondrial DNA. MRPL28 functions within the larger mitochondrial ribosomal complex which is distinct from cytoplasmic ribosomes highlighting its specialized role in maintaining mitochondrial function.

Pathways

The function of MRPL28 is closely tied to the oxidative phosphorylation pathway. This pathway involves the production of ATP via electron transport and chemiosmosis in the mitochondria. MRPL28 directly interacts with other mitochondrial ribosomal proteins to facilitate the translation of mitochondrial-encoded proteins essential for electron transport chain complexes. Changes in MRPL28 expression or function can impact energy metabolism and cellular homeostasis.

Mutations or dysregulation in MRPL28 have been associated with mitochondrial diseases such as mitochondrial myopathy. These disorders often affect energy-intensive tissues leading to symptoms such as muscle weakness or heart problems. Furthermore MRPL28 has connections to neurodegenerative diseases where mitochondrial dysfunction could play a role in disease progression. Understanding the link between MRPL28 and these conditions may offer insights into potential therapeutic strategies.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the bacterial ribosomal protein bL28 family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

See full target information MRPL28
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