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AB187432

Recombinant Human MRPL48 protein (denatured)

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Recombinant Human MRPL48 protein (denatured) is a Human Full Length protein, in the 29 to 212 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

CGI-118, HSPC290, MRPL48, Large ribosomal subunit protein mL48, L48mt, MRP-L48

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SDS-PAGE - Recombinant Human MRPL48 protein (denatured) (AB187432)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MRPL48 protein (denatured) (AB187432)

15% SDS-PAGE analysis of 3μg ab187432.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96GC5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSSGEKPIYSVGGILLSISRPYKTKPTHGIGKYKHLIKAEEPKKKKGKVEVRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSLPEGVRLSVKEHTEEDFKGRFKARPELEELLAKLK","proteinLength":"Full Length","predictedMolecularWeight":"23.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":212,"aminoAcidStart":29,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96GC5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPL48 also known as mitochondrial ribosomal protein L48 is a component of the mitochondrial ribosome. This protein has a mass of approximately 18.7 kDa and plays a role in protein synthesis within mitochondria. MRPL48 locates itself mostly in the mitochondria of cells across various tissues with higher expression levels observed in tissues with high energy demands such as muscle and liver.
Biological function summary

MRPL48 contributes to the formation and function of the mitochondrial ribosome which is responsible for synthesizing proteins that are essential for mitochondrial respiration and energy production. This protein is part of the large subunit of the mitochondrial ribosome which includes many other mitochondrial ribosomal proteins. Together they form a complex responsible for translating mitochondrial mRNA into functional proteins.

Pathways

MRPL48 is actively engaged in mitochondrial translation a critical pathway for maintaining mitochondrial function and energy production. In this pathway it associates with other mitochondrial ribosomal proteins to produce enzymes necessary for the electron transport chain and ATP synthesis. MRPL48 also relates to oxidative phosphorylation where it plays a part in generating cellular energy linking it to proteins such as cytochrome c oxidase subunit IV.

Defects in MRPL48 could relate to mitochondrial dysfunctions which may contribute to disorders like mitochondrial myopathy and mitochondrial complex I deficiency. These conditions often manifest muscle weakness neurological problems and metabolic disturbances. In these disorders MRPL48's interaction with other mitochondrial ribosomal proteins is important as impaired mitochondrial protein synthesis can cause decreased energy production and increased oxidative stress within cells.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the mitochondrion-specific ribosomal protein mL48 family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

See full target information MRPL48
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Complementary Products

Primary Antibodies

AB251194

Anti-MRPL48 antibody [EPR16328] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL48 antibody [EPR16328] - BSA and Azide free (AB251194)

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