Recombinant Human MRPS2 protein is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A T S S A A L P R I L G A G A R A P S R W L G F L G K A T P R P A R P S R R T L G S A T A L M I R E S E D S T D F N D K I L N E P L K H S D F F N V K E L F S V R S L F D A R V H L G H K A G C R H R F M E P Y I F G S R L D H D I I D L E Q T A T H L Q L A L N F T A H M A Y R K G I I L F I S R N R Q F S Y L I E N M A R D C G E Y A H T R Y F R G G M L T N A R L L F G P T V R L P D L I I F L H T L N N I F E P H V A V R D A A K M N I P T V G I V D T N C N P C L I T Y P V P G N D D S P L A V H L Y C R L F Q T A I T R A K E K R Q Q V E A L Y R L Q G Q K E P G D Q G P A H P P G A D M S H S L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Required for mitoribosome formation and stability, and mitochondrial translation.
Alternative names
CGI-91, MRPS2, Small ribosomal subunit protein uS2m, MRP-S2, S2mt
Recombinant Human MRPS2 protein is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9Y399-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A T S S A A L P R I L G A G A R A P S R W L G F L G K A T P R P A R P S R R T L G S A T A L M I R E S E D S T D F N D K I L N E P L K H S D F F N V K E L F S V R S L F D A R V H L G H K A G C R H R F M E P Y I F G S R L D H D I I D L E Q T A T H L Q L A L N F T A H M A Y R K G I I L F I S R N R Q F S Y L I E N M A R D C G E Y A H T R Y F R G G M L T N A R L L F G P T V R L P D L I I F L H T L N N I F E P H V A V R D A A K M N I P T V G I V D T N C N P C L I T Y P V P G N D D S P L A V H L Y C R L F Q T A I T R A K E K R Q Q V E A L Y R L Q G Q K E P G D Q G P A H P P G A D M S H S L
- Accession
- Q9Y399
- Protein length
- Full Length
- Predicted molecular weight
- 35.6 kDa
- Amino acids
- 1 to 296
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Required for mitoribosome formation and stability, and mitochondrial translation.
- Sequence similarities
Belongs to the universal ribosomal protein uS2 family.
- Subcellular localisation
- Mitochondrion
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MRPS2 also known as the mitochondrial ribosomal protein S2 is an essential component of the mitochondrial ribosome. It has a molecular mass of approximately 31.5 kDa. MRPS2 is expressed in the mitochondria across various tissues where it plays a critical role in protein synthesis within the mitochondrial matrix. The protein is part of the small 28S subunit of the mitochondrial ribosome contributing to the translation of mitochondrial-encoded proteins necessary for cellular energy production.
- Biological function summary
MRPS2 participates in the formation of the mitochondrial ribosome by integrating into a large ribosomal complex essential for the initiation and elongation phases of mitochondrial translation. This protein works alongside other mitochondrial ribosomal proteins to ensure the proper synthesis of proteins that drive oxidative phosphorylation. Its role as part of the 28S subunit emphasizes its importance in maintaining mitochondrial function and energy production.
- Pathways
MRPS2 is deeply involved in the mitochondrial protein synthesis pathway an important aspect of cellular energy metabolism. This pathway interfaces with the oxidative phosphorylation pathway where MRPS2 indirectly influences the generation of ATP by affecting the synthesis of enzyme components required for this process. MRPS2 works closely with related proteins such as MRPL44 and MRPS34 highlighting its interconnected role in mitochondrial function and energy conversion.
- Associated diseases and disorders
MRPS2 mutations or dysfunctions link to mitochondrial disorders such as mitochondrial myopathy and chronic progressive external ophthalmoplegia. These disorders often result from impairments in mitochondrial protein synthesis. MRPS2's interactions with proteins like POLG or TWINKLE both associated with mitochondrial DNA replication and maintenance further illustrate the protein's involvement in pathological states affecting the mitochondria. Understanding these connections helps to elucidate the broader implications of MRPS2 in mitochondrial diseases.
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1 product image
SDS-PAGE - Recombinant Human MRPS2 protein (ab171597)
15% SDS-PAGE analysis of 3µg ab171597.
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