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AB171597

Recombinant Human MRPS2 protein (His tag N-Terminus)

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Recombinant Human MRPS2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 296 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

CGI-91, MRPS2, Small ribosomal subunit protein uS2m, MRP-S2, S2mt

1 Images
SDS-PAGE - Recombinant Human MRPS2 protein (His tag N-Terminus) (AB171597)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MRPS2 protein (His tag N-Terminus) (AB171597)

15% SDS-PAGE analysis of 3µg ab171597.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y399

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMATSSAALPRILGAGARAPSRWLGFLGKATPRPARPSRRTLGSATALMIRESEDSTDFNDKILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFMEPYIFGSRLDHDIIDLEQTATHLQLALNFTAHMAYRKGIILFISRNRQFSYLIENMARDCGEYAHTRYFRGGMLTNARLLFGPTVRLPDLIIFLHTLNNIFEPHVAVRDAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRLFQTAITRAKEKRQQVEALYRLQGQKEPGDQGPAHPPGADMSHSL","proteinLength":"Full Length","predictedMolecularWeight":"35.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":296,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y399","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPS2 also known as the mitochondrial ribosomal protein S2 is an essential component of the mitochondrial ribosome. It has a molecular mass of approximately 31.5 kDa. MRPS2 is expressed in the mitochondria across various tissues where it plays a critical role in protein synthesis within the mitochondrial matrix. The protein is part of the small 28S subunit of the mitochondrial ribosome contributing to the translation of mitochondrial-encoded proteins necessary for cellular energy production.
Biological function summary

MRPS2 participates in the formation of the mitochondrial ribosome by integrating into a large ribosomal complex essential for the initiation and elongation phases of mitochondrial translation. This protein works alongside other mitochondrial ribosomal proteins to ensure the proper synthesis of proteins that drive oxidative phosphorylation. Its role as part of the 28S subunit emphasizes its importance in maintaining mitochondrial function and energy production.

Pathways

MRPS2 is deeply involved in the mitochondrial protein synthesis pathway an important aspect of cellular energy metabolism. This pathway interfaces with the oxidative phosphorylation pathway where MRPS2 indirectly influences the generation of ATP by affecting the synthesis of enzyme components required for this process. MRPS2 works closely with related proteins such as MRPL44 and MRPS34 highlighting its interconnected role in mitochondrial function and energy conversion.

MRPS2 mutations or dysfunctions link to mitochondrial disorders such as mitochondrial myopathy and chronic progressive external ophthalmoplegia. These disorders often result from impairments in mitochondrial protein synthesis. MRPS2's interactions with proteins like POLG or TWINKLE both associated with mitochondrial DNA replication and maintenance further illustrate the protein's involvement in pathological states affecting the mitochondria. Understanding these connections helps to elucidate the broader implications of MRPS2 in mitochondrial diseases.
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Specifications

Form

Liquid

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General info

Function

Required for mitoribosome formation and stability, and mitochondrial translation.

Sequence similarities

Belongs to the universal ribosomal protein uS2 family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Required for mitoribosome formation and stability, and mitochondrial translation.
See full target information MRPS2
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