Recombinant Human MRPS28 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRPS28 also known as Mitochondrial Ribosomal Protein S28 is a protein that plays an important role in mitochondrial protein synthesis. It is a component of the small subunit of the mitochondrial ribosome which is important for the translation of mitochondrial mRNAs. This protein has a molecular mass of approximately 12 kDa and is mainly expressed in the mitochondria an organelle present in most eukaryotic cells. As a mitochondrial ribosomal protein MRPS28 is part of the machinery responsible for producing proteins that are essential for mitochondrial function and energy production.

Biological function summary

MRPS28 is involved in the assembly and stability of the mitochondrial ribosomal small subunit complex. It ensures the proper translation of 13 mitochondrial-encoded polypeptides which are components of the oxidative phosphorylation system. MRPS28 interacts with other mitochondrial ribosomal proteins to form a functional ribosome supporting mitochondrial gene expression and cellular energy metabolism. The presence of MRPS28 in this complex is necessary for the maintenance of mitochondrial translation fidelity and efficiency.

Pathways

MRPS28 plays a role in mitochondrial translation and oxidative phosphorylation pathways. It contributes to the synthesis of proteins that are integral to the electron transport chain an important part of energy production in cells. Proteins such as MRPS16 and MRPS18 are also involved within these same pathways working closely with MRPS28 to ensure efficient mitochondrial function. These pathways are essential to provide energy in the form of ATP supporting various cellular processes.

MRPS28 has connections to conditions associated with mitochondrial dysfunction such as mitochondrial myopathy and Leigh syndrome. Research has suggested that mutations affecting MRPS28 could impair mitochondrial translation leading to decreased energy production and resulting in these disorders. Through its role in these diseases MRPS28 is linked with other mitochondrial proteins like MRPL3 which when dysfunctional can also contribute to similar mitochondrial pathologies. Understanding the function and disease associations of MRPS28 may provide insights into potential therapeutic strategies for mitochondrial diseases.