Recombinant Human MS4A6A protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MS4A6A also known as Membrane-Spanning 4-Domains Subfamily A Member 6A is part of the MS4A gene family and plays a role in cellular functions. It has a molecular mass of approximately 22 kDa. MS4A6A is expressed mostly in hematopoietic and immune-related tissues such as the spleen and lymph nodes. The protein structure includes four transmembrane domains which anchors it within the cell membrane allowing for potential interactions with other membrane-associated proteins.

Biological function summary

MS4A6A contributes to the regulation of immune responses and cell cycle processes. It is hypothesized to be part of larger protein complexes given its localization in membrane-rich regions. The expression pattern in immune tissues suggests involvement in modulating immune cell function. Although the exact mechanisms remain partially elucidated evidence suggests MS4A6A may interact with cell cycle regulatory proteins and receptors influencing immune cell signaling and proliferation.

Pathways

This protein appears integral to pathways regulating immune signaling and cell communication. It participates in pathways such as the B-cell receptor (BCR) signaling. Related proteins within these pathways include other members of the MS4A family such as MS4A1 (CD20) which also contributes to immune cell signaling. Its involvement helps relay signals from the cell surface to the inside mediating various downstream effects essential for proper immune function.

MS4A6A has been linked to neurodegenerative diseases including Alzheimer's disease. It may interact with proteins like amyloid-beta peptides through its potential modulation of neuroinflammatory responses. Another disease association includes its involvement in certain lymphoid malignancies where aberrations lead to disrupted cell cycle regulation. Proteins in pathways associated with these diseases such as CD20 often share functional similarities and relevance making MS4A6A a target of interest for therapeutic interventions.