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AB126699

Recombinant Human MSRA protein (His tag N-Terminus)

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Recombinant Human MSRA protein (His tag N-Terminus) is a Human Full Length protein, in the 24 to 235 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Mitochondrial peptide methionine sulfoxide reductase, Peptide-methionine (S)-S-oxide reductase, Protein-methionine-S-oxide reductase, Peptide Met(O) reductase, PMSR, MSRA

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SDS-PAGE - Recombinant Human MSRA protein (His tag N-Terminus) (AB126699)
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SDS-PAGE - Recombinant Human MSRA protein (His tag N-Terminus) (AB126699)

15% SDS-PAGE analysis of 3 μg of ab126699 (MSRA protein).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UJ68

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.29% Sodium chloride, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK","proteinLength":"Full Length","predictedMolecularWeight":"26.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":235,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UJ68","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 'MSRA' protein also known as Methionine Sulfoxide Reductase A is an enzyme that catalyzes the reduction of oxidized methionine residues within proteins. MSRA primarily operates by converting methionine sulfoxide back to methionine therefore playing a critical role in the repair of proteins that have been damaged by oxidative stress. The molecular weight of the MSRA protein typically falls around 25 kDa. Expression of MSRA is found in various tissues with notable levels in the liver kidney brain and heart.
Biological function summary

MSRA contributes to cellular defense against oxidative damage by restoring the normal function of proteins compromised by reactive oxygen species. This enzyme does not form part of a larger complex but acts independently on its substrate. It plays an important role in maintaining protein structure and function under stressful conditions such as during immune responses and aging.

Pathways

MSRA functions are important in the oxidative stress response and redox signaling pathways. It works alongside other antioxidant proteins like Methionine Sulfoxide Reductase B (MSRB) to maintain cellular homeostasis. The supportive roles within these pathways enhance the stability of cell environments protecting the cells from damage induced by external and internal oxidative agents.

MSRA is linked to conditions characterized by increased oxidative stress such as Alzheimer's disease and cardiovascular diseases. Reduced activity of MSRA correlates with higher oxidative stress levels leading to protein dysfunction within the brain and heart. The connections to these diseases often involve interactions with other oxidative stress-targeted proteins like superoxide dismutase and catalase highlighting MSRA's role in maintaining cellular integrity under pathophysiological conditions.
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Specifications

Form

Liquid

Additional notes

ab126699 is purified by conventional chromatography techniques.

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General info

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
See full target information Mitochondrial peptide methionine sulfoxide reductase
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