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AB202218

Recombinant Human MTHFSD protein (His tag N-Terminus)

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Recombinant Human MTHFSD protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 383 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Methenyltetrahydrofolate synthase domain-containing protein, MTHFSD

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SDS-PAGE - Recombinant Human MTHFSD protein (AB202218)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MTHFSD protein (AB202218)

15% SDS PAGE analysis of ab202218 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q2M296

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPRAVGVSKQDIREQIWGYMESQNLADFPRPVHHRIPNFKGASHAAEQLPRLQAFKTARTIKVNPDAPQKSARFFVLESKKTLLVPTPRLRTGLFNKITPPPGATKDILRKCATSQGVRNYSVPIGLDSRVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVSKETPVVTIVHDCQVVDIPEELVEEHDITVDYILTPTRVIATGCKRPKPMGITWFKISLEMMEKIPILRSLRAREQQAGKDVTLQGEHQHLPEPGCQQTVPLSVGRRPPDTPGPETNSMEAAPGSPPGEGAPLAADVYVGNLPGDARVSDLKRALRELGSVPLRLTWQGPRRRAFLHYPDSAAAQQAVSCLQGLRLGTDTLRVALARQQRDK","proteinLength":"Full Length","predictedMolecularWeight":"44.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":383,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q2M296","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MTHFSD also known as Methenyltetrahydrofolate Synthetase Domain Containing is a protein involved in one-carbon metabolism specifically the folate cycle. The protein has a mass of approximately 32 kDa and is expressed across various tissues with notable expression in the liver and brain. MTHFSD contributes to the conversion of tetrahydrofolate (THF) derivatives which are important for DNA synthesis and repair.
Biological function summary

MTHFSD plays a role in cellular methylation processes and is important for proper DNA methylation patterns. This protein does not appear to operate as part of a large complex but interacts with THF directly aiding in the cycling between different folate forms. It influences the cellular availability of methyl groups required for critical metabolic reactions.

Pathways

MTHFSD acts within the folate-mediated one-carbon metabolism pathway which integrates with the methionine cycle. This network is essential for nucleotide biosynthesis and homocysteine remethylation. MTHFSD connects to other proteins involved in these pathways including methionine synthase (MTR) and methylenetetrahydrofolate reductase (MTHFR) highlighting its role in maintaining metabolic homeostasis.

MTHFSD has implications in hyperhomocysteinemia potentially due to disruptions in folate metabolism. The protein's activity also associates with neural tube defects linking its importance to prenatal development. Interaction with proteins such as MTHFR and CBS (cystathionine beta-synthase) highlights its involvement in these disorders emphasizing the need for balanced one-carbon metabolism.
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Specifications

Form

Liquid

Additional notes

ab202218 was purified using conventional chromatography techniques.

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General info

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Product protocols

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Target data

See full target information MTHFSD
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