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AB95496

Recombinant Human mu Crystallin protein

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Recombinant Human mu Crystallin protein is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

THBP, CRYM, Ketimine reductase mu-crystallin, NADP-regulated thyroid-hormone-binding protein

1 Images
SDS-PAGE - Recombinant Human mu Crystallin protein (AB95496)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human mu Crystallin protein (AB95496)

15% SDS-PAGE analysis of 3μg ab95496.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q14894

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSRVPAFLSAAEVEEHLRSSSLLIPPLETALANFSSGPEGGVMQPVRTVVPVTKHRGYLGVMPAYSAAEDALTTKLVTFYEDRGITSVVPSHQATVLLFEPSNGTLLAVMDGNVITAKRTAAVSAIATKFLKPPSSEVLCILGAGVQAYSHYEIFTEQFSFKEVRIWNRTKENAEKFADTVQGEVRVCSSVQEAVAGADVIITVTLATEPILFGEWVKPGAHINAVGASRPDWRELDDELMKEAVLYVDSQEAALKESGDVLLSGAEIFAELGEVIKGVKPAHCEKTTVFKSLGMAVEDTVAAKLIYDSWSSGK","proteinLength":"Full Length","predictedMolecularWeight":"35.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q14894","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Mu Crystallin also known as CRYM is a protein with a molecular weight of approximately 33 kDa. It binds to NADPH functioning as a crystallin-like structure. Mu Crystallin expresses in several tissues with notable presence in the human kidney heart and inner ear. While its original identification was in relation to vertebrate eye lens outside the lens its expression takes on additional roles that align with its involvement in thyroid hormone binding.
Biological function summary

Mu Crystallin plays a part in the regulation of thyroid hormones by acting as a carrier protein for triiodothyronine (T3). It does not belong to any known complex but shows distinction in its binding capabilities. By binding with T3 mu Crystallin modulates the availability of this hormone affecting local cellular environments and hormonal pathways. This interaction influences the normal signaling of thyroid hormones which are essential for maintaining many physiological processes.

Pathways

Mu Crystallin is involved in key processes related to thyroid hormone signaling and metabolic regulation. It fits importantly into the thyroid hormone pathway where it impacts the transportation and eventual metabolism of T3. In relation to this context mu Crystallin interacts with proteins such as thyroid hormone receptors and other binding proteins inherent in the metabolic pathways.

Defects and dysregulation in mu Crystallin function connect to non-syndromic deafness and depressive disorders. Through its role in hormone regulation mu Crystallin's dysfunctions can impact neurotransmitter levels which may contribute to depressive conditions. Furthermore its relationship with other thyroid hormone-related proteins suggests implications in auditory impairments where alterations in hormone availability affect inner ear health.
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Specifications

Form

Liquid

Additional notes

ab95496 is purified using conventional chromatography techniques.

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General info

Function

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.

Sequence similarities

Belongs to the ornithine cyclodeaminase/mu-crystallin family.

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Product protocols

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Target data

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
See full target information CRYM
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Complementary Products

Primary Antibodies

AB314876

Anti-mu Crystallin antibody [EPR28406-56]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-mu Crystallin antibody [EPR28406-56] (AB314876)

  • 0
  • 0
Primary Antibodies

AB76467

Anti-Alpha B Crystallin antibody [EPR2752]

RabMAb|Recombinant

Western blot - Anti-Alpha B Crystallin antibody [EPR2752] (AB76467)

  • 5
  • 2
Primary Antibodies

AB240636

Anti-Ctip2 antibody [EPR23120-25]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ctip2 antibody [EPR23120-25] (AB240636)

  • 5
  • 1
Primary Antibodies

AB31940

Anti-TBR1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBR1 antibody (AB31940)

  • 4
  • 32

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