Recombinant Human MUC4 protein is a Human Fragment protein, expressed in Wheat germ, with >=80% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >=80%
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
G V S L F P Y G A D A G D L E F V R R T V D F T S P L F K P A T G F P L G S S L R D S L Y F T D N G Q I I F P E S D Y Q I F S Y P N P L P T G F T G R D P V A L V A P F W D D A D F S T G R G T T F Y Q E Y E T F Y G E H S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978). These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978). Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
Alternative names
Mucin-4, MUC-4, Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, ASGP, MUC4
Recommended products
Recombinant Human MUC4 protein is a Human Fragment protein, expressed in Wheat germ, with >=80% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >=80%
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q99102-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 1.24% Tris HCl, 0.307% Glutathione
Sequence info
Amino acid sequence
- G V S L F P Y G A D A G D L E F V R R T V D F T S P L F K P A T G F P L G S S L R D S L Y F T D N G Q I I F P E S D Y Q I F S Y P N P L P T G F T G R D P V A L V A P F W D D A D F S T G R G T T F Y Q E Y E T F Y G E H S
- Accession
- Q99102
- Protein length
- Fragment
- Predicted molecular weight
- 37.84 kDa
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
Glutathione Sepharose
General info
- Function
Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978). These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978). Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
- Post-translational modifications
Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human MUC4 protein (ab130768)
12.5% SDS-PAGE Stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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