Recombinant Human MX1 protein is a Human Full Length protein, in the 1 to 662 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M V V S E V D I A K A D P A A A S H P L L L N G D A T V A Q K N P G S V A E N N L C S Q Y E E K V R P C I D L I D S L R A L G V E Q D L A L P A I A V I G D Q S S G K S S V L E A L S G V A L P R G S G I V T R C P L V L K L K K L V N E D K W R G K V S Y Q D Y E I E I S D A S E V E K E I N K A Q N A I A G E G M G I S H E L I T L E I S S R D V P D L T L I D L P G I T R V A V G N Q P A D I G Y K I K T L I K K Y I Q R Q E T I S L V V V P S N V D I A T T E A L S M A Q E V D P E G D R T I G I L T K P D L V D K G T E D K V V D V V R N L V F H L K K G Y M I V K C R G Q Q E I Q D Q L S L S E A L Q R E K I F F E N H P Y F R D L L E E G K A T V P C L A E K L T S E L I T H I C K S L P L L E N Q I K E T H Q R I T E E L Q K Y G V D I P E D E N E K M F F L I D K V N A F N Q D I T A L M Q G E E T V G E E D I R L F T R L R H E F H K W S T I I E N N F Q E G H K I L S R K I Q K F E N Q Y R G R E L P G F V N Y R T F E T I V K Q Q I K A L E E P A V D M L H T V T D M V R L A F T D V S I K N F E E F F N L H R T A K S K I E D I R A E Q E R E G E K L I R L H F Q M E Q I V Y C Q D Q V Y R G A L Q K V R E K E L E E E K K K K S W D F G A F Q S S S A T D S S M E E I F Q H L M A Y H Q E A S K R I S S H I P L I I Q F F M L Q T Y G Q Q L Q K A M L Q L L Q D K D T Y S W L L K E R S D T S D K R K F L K E R L A R L T Q A R R R L A Q F P G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
Alternative names
Interferon-induced GTP-binding protein Mx1, Interferon-induced protein p78, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, IFI-78K, MX1
Recommended products
Recombinant Human MX1 protein is a Human Full Length protein, in the 1 to 662 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P20591-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 89% PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M V V S E V D I A K A D P A A A S H P L L L N G D A T V A Q K N P G S V A E N N L C S Q Y E E K V R P C I D L I D S L R A L G V E Q D L A L P A I A V I G D Q S S G K S S V L E A L S G V A L P R G S G I V T R C P L V L K L K K L V N E D K W R G K V S Y Q D Y E I E I S D A S E V E K E I N K A Q N A I A G E G M G I S H E L I T L E I S S R D V P D L T L I D L P G I T R V A V G N Q P A D I G Y K I K T L I K K Y I Q R Q E T I S L V V V P S N V D I A T T E A L S M A Q E V D P E G D R T I G I L T K P D L V D K G T E D K V V D V V R N L V F H L K K G Y M I V K C R G Q Q E I Q D Q L S L S E A L Q R E K I F F E N H P Y F R D L L E E G K A T V P C L A E K L T S E L I T H I C K S L P L L E N Q I K E T H Q R I T E E L Q K Y G V D I P E D E N E K M F F L I D K V N A F N Q D I T A L M Q G E E T V G E E D I R L F T R L R H E F H K W S T I I E N N F Q E G H K I L S R K I Q K F E N Q Y R G R E L P G F V N Y R T F E T I V K Q Q I K A L E E P A V D M L H T V T D M V R L A F T D V S I K N F E E F F N L H R T A K S K I E D I R A E Q E R E G E K L I R L H F Q M E Q I V Y C Q D Q V Y R G A L Q K V R E K E L E E E K K K K S W D F G A F Q S S S A T D S S M E E I F Q H L M A Y H Q E A S K R I S S H I P L I I Q F F M L Q T Y G Q Q L Q K A M L Q L L Q D K D T Y S W L L K E R S D T S D K R K F L K E R L A R L T Q A R R R L A Q F P G
- Accession
- P20591
- Protein length
- Full Length
- Predicted molecular weight
- 77.9 kDa
- Amino acids
- 1 to 662
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab187486 was purified using conventional chromatography techniques.
General info
- Function
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
- Sequence similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
- Post-translational modifications
ISGylated.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
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1 product image
SDS-PAGE - Recombinant Human MX1 protein (ab187486)
15% SDS-PAGE analysis of ab187486 (3 μg).
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