Recombinant Human Myelin Protein Zero is a Human Full Length protein, in the 1 to 258 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M L R A P A P A P A M A P G A P S S S P S P I L A V L L F S S L V L S P A Q A I V V Y T D R E A H G A V G S R V T L H C S F W S S E W V S D D I S F T W R Y Q P E G G R D A I S I F H Y A K G Q P Y I D E V G T F K E R I Q W V G D P R W K D G S I V I H N L D Y S D N G T F T C D V K N P P D I V G K T S Q V T L Y V F E K V P T R Y G V V L G A V I G G V L G V V L L L L L L F Y V V R Y C W L R R Q A A L Q R R L S A M E K G K L H K P G K D A S K R G R Q T P V L Y A M L D H S R S T K A V S E K K A K G L G E S R K D K K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
Alternative names
Myelin protein P0, Myelin peripheral protein, Myelin protein zero, MPP, MPZ
Recommended products
Recombinant Human Myelin Protein Zero is a Human Full Length protein, in the 1 to 258 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P25189-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M L R A P A P A P A M A P G A P S S S P S P I L A V L L F S S L V L S P A Q A I V V Y T D R E A H G A V G S R V T L H C S F W S S E W V S D D I S F T W R Y Q P E G G R D A I S I F H Y A K G Q P Y I D E V G T F K E R I Q W V G D P R W K D G S I V I H N L D Y S D N G T F T C D V K N P P D I V G K T S Q V T L Y V F E K V P T R Y G V V L G A V I G G V L G V V L L L L L L F Y V V R Y C W L R R Q A A L Q R R L S A M E K G K L H K P G K D A S K R G R Q T P V L Y A M L D H S R S T K A V S E K K A K G L G E S R K D K K
- Accession
- P25189
- Protein length
- Full Length
- Predicted molecular weight
- 54.12 kDa
- Amino acids
- 1 to 258
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
- Sequence similarities
Belongs to the myelin P0 protein family.
- Post-translational modifications
N-glycosylated; contains sulfate-substituted glycan.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Myelin protein zero sometimes called MPZ or P0 is a structural protein in the peripheral nervous system. It has a molecular mass of approximately 30 kDa. Myelin protein zero is mostly found in Schwann cells where it plays an important role in the formation of the myelin sheath. This protein facilitates the adhesion between layers of the myelin membrane contributing to the compact structure of the myelin sheath surrounding nerve fibers.
- Biological function summary
Several functions of nerve insulating layers involve myelin protein zero. It forms part of the myelin sheath critical for effective nerve signal transmission. The protein is associated with the Ig superfamily and interacts with other myelin components to maintain integrity and functionality. Myelin protein zero also affects the clustering of specific proteins and lipids within the myelin sheath making it an important component in maintaining the stability and function of peripheral nerves.
- Pathways
Several important signal transmission processes involve the interactions of myelin protein zero. It is involved in the myelination pathway which is essential for insulating nerve fibers and speeding up action potential propagation. The protein is closely related to connexin 32 in this pathway another protein involved in maintaining the proper function of myelinated neurons. This coordination helps ensure efficient communication in the peripheral nervous system.
- Associated diseases and disorders
Several neurological conditions link to abnormalities in myelin protein zero. Mutations in the gene encoding this protein can lead to Charcot-Marie-Tooth disease type 1B a hereditary neuropathy characterized by muscle weakness and sensory loss. Alterations in myelin protein zero are also associated with Dejerine-Sottas syndrome a severe neuropathy involving early-onset muscle weakness. The protein's relation to other myelin proteins like PMP22 often signifies its role in the molecular mechanisms underlying these demyelinating disorders.
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1 product image
SDS-PAGE - Recombinant Human Myelin Protein Zero (ab114281)
12.5% SDS-PAGE analysis of Myelin Protein Zero protein (ab114281) Stained with Coomassie Blue.
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