Recombinant human Myostatin Propeptide protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myostatin Propeptide also known as myostatin peptide or anti-myostatin acts as an important regulator by binding to its parent myostatin protein. This binding prevents the myostatin protein from interacting with its receptors modulating its activity. Myostatin Propeptide has a molecular weight of approximately 40 kDa. It is primarily expressed in skeletal muscle tissue reflecting its role in muscle biology. Myostatin Propeptide's interaction with myostatin provides an essential control mechanism within muscle development.

Biological function summary

Myostatin Propeptide inhibits the function of myostatin a member of the Transforming Growth Factor-beta (TGF-beta) superfamily. Myostatin typically suppresses muscle growth so the propeptide acts as a decoy permitting muscle hypertrophy by blocking myostatin activity. This regulation is important in maintaining muscle mass and function. The propeptide does not usually function as part of a large complex instead acting directly to neutralize myostatin in the extracellular environment.

Pathways

Myostatin and its propeptide play major roles in the TGF-beta signaling pathway. This pathway is significant in regulating cell growth and differentiation in various tissues including muscle. Myostatin Propeptide's inhibition of myostatin leads to increased activation of the Akt/mTOR pathway promoting protein synthesis and muscle growth. It also interacts with related proteins such as follistatin another myostatin inhibitor which enhances the modulation of muscle mass through similar mechanisms.

Myostatin Propeptide has relevance in conditions related to muscle wasting such as muscular dystrophy and cachexia. By antagonizing myostatin the propeptide can potentially alleviate muscle degeneration in these conditions. Its role is also significant in sarcopenia an age-related loss of muscle mass providing a target for therapeutic approaches. In these disorders the propeptide's action may involve interactions with proteins like activin receptor type IIB which is involved in the signaling pathways mediated by myostatin.