Recombinant Human Myotrophin protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myotrophin also known as V-1 is a protein that facilitates numerous cellular activities. This protein has a molecular weight of approximately 12 kDa and is expressed in several tissues including cardiac and skeletal muscles. It shows high presence in the brain and heart suggesting significant roles in these organs. Myotrophin's ability to modulate multiple cellular functions makes it a target of interest in scientific research focused on cardiac function and neurobiology.

Biological function summary

This protein plays a role in modulating cardiac muscle cell hypertrophy directly affecting heart muscle growth. Myotrophin participates in forming a complex with other proteins such as calpactin which influences actin filament dynamics. This interaction is essential for cellular structural maintenance and function. Additionally myotrophin acts as a transcription factor modulator impacting the expression of genes associated with cellular growth and differentiation.

Pathways

Myotrophin integrates into signaling networks like the NF-kB and MAPK pathways. These pathways are critical for cellular responses to stress and inflammation. Myotrophin interacts with proteins such as p65 (a subunit of NF-kB) to modulate transcriptional activities that regulate these pathways. By influencing these pathways myotrophin plays a substantial role in cellular adaptation and stress response mechanisms.

Myotrophin associates with cardiovascular diseases like hypertrophic cardiomyopathy and heart failure. It contributes to the pathological remodeling of heart tissue through its impact on hypertrophy. Additionally it shows implications in neurodegenerative diseases linked through the protein α-synuclein. Alterations in myotrophin levels and function can disrupt normal cellular processes leading to the progression of these critical diseases.