Recombinant Human Myozenin 1 protein (denatured) is a Human Full Length protein, in the 1 to 299 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M P L S G T P A P N K K R K S S K L I M E L T G G G Q E S S G L N L G K K I S V P R D V M L E E L S L L T N R G S K M F K L R Q M R V E K F I Y E N H P D V F S D S S M D H F Q K F L P T V G G Q L G T A G Q G F S Y S K S N G R G G S Q A G G S G S A G Q Y G S D Q Q H H L G S G S G A G G T G G P A G Q A G R G G A A G T A G V G E T G S G D Q A G G E G K H I T V F K T Y I S P W E R A M G V D P Q Q K M E L G I D L L A Y G A K A E L P K Y K S F N R T A M P Y G G Y E K A S K R M T F Q M P K F D L G P L L S E P L V L Y N Q N L S N R P S F N R T P I P W L S S G E P V D Y N V D I G I P L D G E T E E L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Alternative names
MYOZ, MYOZ1, Myozenin-1, Calsarcin-2, Protein FATZ
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Recombinant Human Myozenin 1 protein (denatured) is a Human Full Length protein, in the 1 to 299 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9NP98-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M P L S G T P A P N K K R K S S K L I M E L T G G G Q E S S G L N L G K K I S V P R D V M L E E L S L L T N R G S K M F K L R Q M R V E K F I Y E N H P D V F S D S S M D H F Q K F L P T V G G Q L G T A G Q G F S Y S K S N G R G G S Q A G G S G S A G Q Y G S D Q Q H H L G S G S G A G G T G G P A G Q A G R G G A A G T A G V G E T G S G D Q A G G E G K H I T V F K T Y I S P W E R A M G V D P Q Q K M E L G I D L L A Y G A K A E L P K Y K S F N R T A M P Y G G Y E K A S K R M T F Q M P K F D L G P L L S E P L V L Y N Q N L S N R P S F N R T P I P W L S S G E P V D Y N V D I G I P L D G E T E E L
- Accession
- Q9NP98
- Protein length
- Full Length
- Predicted molecular weight
- 34.1 kDa
- Amino acids
- 1 to 299
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
- Sequence similarities
Belongs to the myozenin family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Myozenin 1 also known as calsarcin-2 is a protein expressed mainly in skeletal muscle with a molecular weight of approximately 35 kDa. It connects protein structures at the Z-disks in muscle cells. Myozenin 1 links to other important muscle proteins such as alpha-actinin and gamma-filamin. Through these interactions it helps maintain structural integrity and transmission of force within muscle fibers.
- Biological function summary
The role of Myozenin 1 extends beyond structural support in muscle. It modulates signal transduction pathways essential for muscle function and adaptation. This protein forms part of a complex with calcineurin a phosphatase involved in muscle-specific gene expression control. By regulating calcineurin activity Myozenin 1 influences muscle fiber type composition and response to physiological stimuli.
- Pathways
Myozenin 1 participates in the calcineurin-NFAT signaling pathway which is a critical regulator of muscle development and adaptation. While Myozenin 1 itself interacts directly with calcineurin it also has indirect associations with proteins like NFAT that mediate its downstream effects. These pathways play important roles in muscle plasticity and response to mechanical stress.
- Associated diseases and disorders
Alterations in Myozenin 1 expression or function may relate to conditions such as muscle weakness and hypertrophic cardiomyopathy. Myozenin 1 interacts with proteins like calcineurin and disruptions in this relationship can lead to abnormal muscle signaling and pathological changes. Research continues to explore the direct contributions of Myozenin 1 to muscle-related diseases and their underlying molecular mechanisms.
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1 product image
SDS-PAGE - Recombinant Human Myozenin 1 protein (denatured) (ab168067)
3 μg ab168067 on 15% SDS-PAGE
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