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AB168067

Recombinant Human Myozenin 1 protein (denatured) (His tag N-Terminus)

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Recombinant Human Myozenin 1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 299 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

MYOZ, MYOZ1, Myozenin-1, Calsarcin-2, Protein FATZ

1 Images
SDS-PAGE - Recombinant Human Myozenin 1 protein (denatured) (His tag N-Terminus) (AB168067)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Myozenin 1 protein (denatured) (His tag N-Terminus) (AB168067)

3 μg ab168067 on 15% SDS-PAGE

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NP98

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMPLSGTPAPNKKRKSSKLIMELTGGGQESSGLNLGKKISVPRDVMLEELSLLTNRGSKMFKLRQMRVEKFIYENHPDVFSDSSMDHFQKFLPTVGGQLGTAGQGFSYSKSNGRGGSQAGGSGSAGQYGSDQQHHLGSGSGAGGTGGPAGQAGRGGAAGTAGVGETGSGDQAGGEGKHITVFKTYISPWERAMGVDPQQKMELGIDLLAYGAKAELPKYKSFNRTAMPYGGYEKASKRMTFQMPKFDLGPLLSEPLVLYNQNLSNRPSFNRTPIPWLSSGEPVDYNVDIGIPLDGETEEL","proteinLength":"Full Length","predictedMolecularWeight":"34.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":299,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NP98","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myozenin 1 also known as calsarcin-2 is a protein expressed mainly in skeletal muscle with a molecular weight of approximately 35 kDa. It connects protein structures at the Z-disks in muscle cells. Myozenin 1 links to other important muscle proteins such as alpha-actinin and gamma-filamin. Through these interactions it helps maintain structural integrity and transmission of force within muscle fibers.
Biological function summary

The role of Myozenin 1 extends beyond structural support in muscle. It modulates signal transduction pathways essential for muscle function and adaptation. This protein forms part of a complex with calcineurin a phosphatase involved in muscle-specific gene expression control. By regulating calcineurin activity Myozenin 1 influences muscle fiber type composition and response to physiological stimuli.

Pathways

Myozenin 1 participates in the calcineurin-NFAT signaling pathway which is a critical regulator of muscle development and adaptation. While Myozenin 1 itself interacts directly with calcineurin it also has indirect associations with proteins like NFAT that mediate its downstream effects. These pathways play important roles in muscle plasticity and response to mechanical stress.

Alterations in Myozenin 1 expression or function may relate to conditions such as muscle weakness and hypertrophic cardiomyopathy. Myozenin 1 interacts with proteins like calcineurin and disruptions in this relationship can lead to abnormal muscle signaling and pathological changes. Research continues to explore the direct contributions of Myozenin 1 to muscle-related diseases and their underlying molecular mechanisms.
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Specifications

Form

Liquid

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General info

Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Sequence similarities

Belongs to the myozenin family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
See full target information MYOZ1
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Complementary Products

Primary Antibodies

AB197660

Anti-Myozenin 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myozenin 1 antibody (AB197660)

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