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AB169888

Recombinant Human Myozenin 2 protein

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Recombinant Human Myozenin 2 protein is a Human Full Length protein, in the 1 to 264 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

C4orf5, MYOZ2, Myozenin-2, Calsarcin-1, FATZ-related protein 2

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

T7 tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NPC6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGEFMLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL","proteinLength":"Full Length","predictedMolecularWeight":"30 kDa","actualMolecularWeight":null,"aminoAcidEnd":264,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NPC6","tags":[{"tag":"T7","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Myozenin 2 also known as calsarcin-1 mechanically functions as a scaffold protein that anchors filamentous actin to the sarcomeric Z-disc in striated muscles. It weighs approximately 32 kDa. Myozenin 2 is primarily expressed in cardiac and skeletal muscle tissues where it plays an important role in maintaining the structural integrity of muscle fibers. Its interaction with other proteins at the Z-disc is important for muscle function.
Biological function summary

Myozenin 2 contributes to the regulation of muscle contraction and signal transduction within muscle cells. It forms part of a multiprotein complex at the Z-disc where it interfaces with proteins such as telethonin and myotilin. This positioning aids in the transmission of mechanical and signaling information necessary for muscle adaptation and maintenance.

Pathways

Myozenin 2 has roles in the regulation of muscle hypertrophy and myopathy pathways. This protein interacts closely with calcineurin a phosphatase involved in calcium-dependent signaling pathways that regulate muscle growth and differentiation. Additionally Myozenin 2 can affect protein kinase C pathways which are essential for modulating the cellular responses to mechanical stress in muscle tissues.

Myozenin 2 is linked to conditions such as familial hypertrophic cardiomyopathy and muscular dystrophy. Changes in the expression or function of Myozenin 2 can lead to disrupted Z-disc integrity and impaired muscle function. In cardiomyopathy Myozenin 2's interaction with calcineurin becomes relevant as alterations in this interaction may contribute to the pathogenesis. In muscular dystrophy its relationship with telethonin becomes significant influencing the structural stability of muscle cells.
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Specifications

Form

Liquid

Additional notes

The final product was refolded using a unique “temperature shift inclusion body refolding” technology and chromatographically purified.

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General info

Function

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Sequence similarities

Belongs to the myozenin family.

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Product protocols

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Target data

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
See full target information MYOZ2
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Primary Antibodies

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Primary Antibodies

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