Recombinant Human NACA1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NACA1 also known as Nascent Polypeptide-Associated Complex Alpha-1 is a vital protein in cells with a molecular mass of around 21 kDa. It plays a big role as a transcription factor and coordinates the synthesis and proper folding of nascent polypeptides. This protein shows high expression in various tissues including muscle brain and liver. As a multifunctional player NACA1 assists in safeguarding polypeptides emerging during protein synthesis ensuring they achieve correct conformation and function.

Biological function summary

NACA1 modulates transcriptional activity interacting with particular sequences in DNA to affect gene expression. It forms a part of the nascent polypeptide-associated complex (NAC) that helps modulate developing polypeptides and ribosome-associated processes. By working in tandem with other proteins NACA1 not only contributes to protein folding but also aids in the regulation of stress responses. This highlights its importance in ensuring proteins function correctly under various cellular conditions.

Pathways

NACA1 engages in the regulation of protein homeostasis and gene expression pathways. It is involved in the unfolded protein response (UPR) and interacts with other ribosome-associated proteins. NACA1 plays a role in stress-response pathways ensuring proteins are correctly processed and folded under stress conditions. It may interact with other proteins like Hsp70 and ribosomal proteins to enhance protein quality control ensuring normal cellular function.

NACA1's dysregulation relates to conditions such as myopathies and cancer. Altered expression or function can disrupt normal stress response pathways resulting in muscle weakness or tumor progression. Researchers have noted its potential link with BRCA1-associated breast cancer and impacts seen in muscular diseases suggesting it may influence disease progression through its interaction with genes and proteins central to these disorders. Understanding NACA1’s role can support the development of new therapeutic strategies for these conditions.