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AB181935

Recombinant Human NAIF1 protein (His tag N-Terminus)

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Recombinant Human NAIF1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 327 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C9orf90, NAIF1, Nuclear apoptosis-inducing factor 1

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SDS-PAGE - Recombinant Human NAIF1 protein (His tag N-Terminus) (AB181935)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NAIF1 protein (His tag N-Terminus) (AB181935)

15% SDS-PAGE analysis of 3 μg ab181935.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q69YI7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAVPAKKRKMNFSEREVEIIVEELELKKHLLVNHFNAGVPLAAKSAAWHGILRRVNAVATCRRELPEVKKKWSDLKTEVRRKVAQVRAAVEGGEAPGPTEEDGAGGPGTGGGSGGGGPAVAPVLLTPMQQRICNLLGEATIISLPSTTEIHPVALGPSATAAAATVTLTQIPTETTYHTLEEGVVEYCTAEAPPPLPPETPVDMMAQHADTSVKPQALKSRIALNSAKLIQEQRVTNLHVKEIAQHLEQQNDLLQMIRRSQEVQACAQERQAQAMEGTQAALSVLIQVLRPMIKDFRRYLQSNTANPAPASDPGQVAQNGQPDSIIQ","proteinLength":"Full Length","predictedMolecularWeight":"37.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":327,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q69YI7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The nuclear apoptosis-inducing factor 1 (NAIF1) also known as Naif1 is a protein with a mass of approximately 45 kDa. It plays an important role in the regulation of apoptosis a process that is essential for removing damaged or unnecessary cells. NAIF1 contains a nuclear localization signal which allows it to enter the nucleus and exert its functions. Expression of NAIF1 occurs widely in human tissues with higher levels observed in the testis and heart indicating its relevance in these organs.
Biological function summary

This protein promotes cell death through apoptosis. It triggers nuclear changes characteristic of apoptosis such as chromatin condensation and nucleosomal DNA fragmentation. Current research suggests that NAIF1 operates independently rather than as part of a protein complex involved in apoptotic pathways. Its apoptotic activity makes it important for maintaining cellular homeostasis especially in tissues with high turnover rates.

Pathways

NAIF1's role extends mainly to the regulation of apoptotic pathways. It interacts with cellular components related to the intrinsic apoptosis pathway. NAIF1 has shown connections with proteins such as BAX which plays a direct role in the release of pro-apoptotic factors from mitochondria. These interactions ensure precise control over cellular death processes maintaining tissue integrity and function.

Research links NAIF1 with certain cancers such as testicular and cardiac diseases. In cancer dysregulation of NAIF1 can lead to abnormal cell survival contributing to tumor growth. The NAIF1 interaction with proteins like BAX can influence cancer progression by modulating apoptotic activities. In cardiac pathologies altered NAIF1 expression may affect cardiomyocyte apoptosis impacting heart function and potentially contributing to cardiac disorders.
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Specifications

Form

Liquid

Additional notes

ab181935 was purified using conventional chromatography techniques.

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General info

Function

Induces apoptosis.

Sequence similarities

Belongs to the NAIF1 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Induces apoptosis.
See full target information NAIF1
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