Recombinant Human NANOGP8 protein (denatured) is a Human Full Length protein, in the 1 to 305 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S V D P A C P Q S L P C F E A S D C K E S S P M P V I C G P E E N Y P S L Q M S S A E M P H T E T V S P L P S S M D L L I Q D S P D S S T S P K G K Q P T S A E N S V A K K E D K V P V K K Q K T R T V F S S T Q L C V L N D R F Q R Q K Y L S L Q Q M Q E L S N I L N L S Y K Q V K T W F Q N Q R M K S K R W Q K N N W P K N S N G V T Q K A S A P T Y P S L Y S S Y H Q G C L V N P T G N L P M W S N Q T W N N S T W S N Q T Q N I Q S W S N H S W N T Q T W C T Q S W N N Q A W N S P F Y N C G E E S L Q S C M H F Q P N S P A S D L E A A L E A A G E G L N V I Q Q T T R Y F S T P Q T M D L F L N Y S M N M Q P E D V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.
Alternative names
Homeobox protein NANOGP8, NANOGP8
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Recombinant Human NANOGP8 protein (denatured) is a Human Full Length protein, in the 1 to 305 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q6NSW7-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 5% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris-HCl buffer
Sequence info
Amino acid sequence
- M S V D P A C P Q S L P C F E A S D C K E S S P M P V I C G P E E N Y P S L Q M S S A E M P H T E T V S P L P S S M D L L I Q D S P D S S T S P K G K Q P T S A E N S V A K K E D K V P V K K Q K T R T V F S S T Q L C V L N D R F Q R Q K Y L S L Q Q M Q E L S N I L N L S Y K Q V K T W F Q N Q R M K S K R W Q K N N W P K N S N G V T Q K A S A P T Y P S L Y S S Y H Q G C L V N P T G N L P M W S N Q T W N N S T W S N Q T Q N I Q S W S N H S W N T Q T W C T Q S W N N Q A W N S P F Y N C G E E S L Q S C M H F Q P N S P A S D L E A A L E A A G E G L N V I Q Q T T R Y F S T P Q T M D L F L N Y S M N M Q P E D V
- Accession
- Q6NSW7
- Protein length
- Full Length
- Predicted molecular weight
- 34.6 kDa
- Amino acids
- 1 to 305
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation.
- Sequence similarities
Belongs to the Nanog homeobox family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NANOGP8 also known as NANOG pseudogene 8 is a retrogene with a molecular mass of approximately 35 kDa. It originates from the NANOG gene which is important for maintaining pluripotency in stem cells. NANOGP8 is generally not expressed in normal tissues but is found in various cancerous tissues and cancer stem cells. Its expression pattern suggests a role in abnormal cell growth and differentiation.
- Biological function summary
NANOGP8 is involved in processes that regulate cell proliferation and differentiation. It does not form part of any known protein complex but shares functional characteristics with NANOG. NANOGP8 contributes to maintaining the undifferentiated state and self-renewal capacity of cancer stem cells giving rise to its increased expression in tumors.
- Pathways
NANOGP8 interacts with cellular pathways involving pluripotency and differentiation. It plays a role in pathways that include Wnt and Hedgehog which are critical for cell cycle regulation and development. NANOGP8's activity relates to proteins such as β-catenin (in Wnt pathways) and GLI family zinc finger proteins (in Hedgehog pathways) which are vital in controlling cell fate and patterning during development.
- Associated diseases and disorders
NANOGP8 shows strong associations with various cancers including colorectal and prostate cancer. NANOGP8's expression in tumors links it to pathways involving other important proteins like p53 known for its tumor suppressor functions and c-MYC which is implicated in cell proliferation and growth. Its study in these contexts may offer insights into cancer progression and resistance to therapy.
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SDS-PAGE - Recombinant Human NANOGP8 protein (denatured) (ab167873)
15% SDS-PAGE analysis of ab167873 (3µg)
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