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AB99392

Recombinant Human NANP protein (His tag N-Terminus)

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Recombinant Human NANP protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 248 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C20orf147, HDHD4, NANP, N-acylneuraminate-9-phosphatase, Haloacid dehalogenase-like hydrolase domain-containing protein 4, Neu5Ac-9-Pase

1 Images
SDS-PAGE - Recombinant Human NANP protein (AB99392)
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SDS-PAGE - Recombinant Human NANP protein (AB99392)

15% SDS-PAGE analysis of 3μg ab99392.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8TBE9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDCKVSMST","proteinLength":"Full Length","predictedMolecularWeight":"31.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":248,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8TBE9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NANP protein also known as NANP repeat exhibits a repeating structure found in the circumsporozoite protein of Plasmodium falciparum. It weighs approximately 45 kDa. This protein is specifically expressed on the surface of the sporozoite stage of the malaria parasite. The NANP sequence plays a critical role in the sporozoite's ability to interact with the surrounding environment and aids its mobility and infection process within the host.
Biological function summary

The NANP repeat sequence is integral to the structural framework of the circumsporozoite protein. The circumsporozoite protein forms a protective coat around the sporozoite contributing to its survival and infectivity. The repetitive nature of the NANP sequence serves as a repetitive immunological target for antibodies making it a focus for vaccine development. Although it does not form a stable complex with other proteins its structural motif facilitates the parasite's ability to evade the host immune response during initial infection stages.

Pathways

The NANP repeat significantly impacts the malaria infection process in humans. It participates in the invasion pathway aiding Plasmodium falciparum's entry into liver cells. This protein is related to proteins like merozoite surface protein 1 (MSP1) which is involved during subsequent stages of malaria infection. Understanding NANP's role helps researchers trace its involvement in the lifecycle progression of the parasite and its development inside the host.

The NANP sequence is closely associated with malaria pathogenesis. Its presence as an antigenic determinant implicates it in potential vaccine targets against malaria. Researchers have noted that NANP's interaction with human antibodies forms a critical part of immune evasion strategies used by the parasite. Proteins like antigens EBA175 associated with erythrocyte invasion are also important in understanding the broader implications of NANP in the persistence and severity of Plasmodium falciparum infections.
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Specifications

Form

Liquid

Additional notes

ab99392 is purified using conventional chromatography techniques.

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General info

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. NANP family.

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Product protocols

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Target data

See full target information NANP
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