Recombinant Human NANP protein is a Human Full Length protein, in the 1 to 248 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M R G S H H H H H H G M A S M T G G Q Q M G R D L Y D D D D K D R W G S M G L S R V R A V F F D L D N T L I D T A G A S R R G M L E V I K L L Q S K Y H Y K E E A E I I C D K V Q V K L S K E C F H P Y N T C I T D L R T S H W E E A I Q E T K G G A A N R K L A E E C Y F L W K S T R L Q H M T L A E D V K A M L T E L R K E V R L L L L T N G D R Q T Q R E K I E A C A C Q S Y F D A V V V G G E Q R E E K P A P S I F Y Y C C N L L G V Q P G D C V M V G D T L E T D I Q G G L N A G L K A T V W I N K N G I V P L K S S P V P H Y M V S S V L E L P A L L Q S I D C K V S M S T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
C20orf147, HDHD4, NANP, N-acylneuraminate-9-phosphatase, Haloacid dehalogenase-like hydrolase domain-containing protein 4, Neu5Ac-9-Pase
Recommended products
Recombinant Human NANP protein is a Human Full Length protein, in the 1 to 248 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8TBE9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M R G S H H H H H H G M A S M T G G Q Q M G R D L Y D D D D K D R W G S M G L S R V R A V F F D L D N T L I D T A G A S R R G M L E V I K L L Q S K Y H Y K E E A E I I C D K V Q V K L S K E C F H P Y N T C I T D L R T S H W E E A I Q E T K G G A A N R K L A E E C Y F L W K S T R L Q H M T L A E D V K A M L T E L R K E V R L L L L T N G D R Q T Q R E K I E A C A C Q S Y F D A V V V G G E Q R E E K P A P S I F Y Y C C N L L G V Q P G D C V M V G D T L E T D I Q G G L N A G L K A T V W I N K N G I V P L K S S P V P H Y M V S S V L E L P A L L Q S I D C K V S M S T
- Accession
- Q8TBE9
- Protein length
- Full Length
- Predicted molecular weight
- 31.9 kDa
- Amino acids
- 1 to 248
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab99392 is purified using conventional chromatography techniques.
General info
- Sequence similarities
Belongs to the HAD-like hydrolase superfamily. NANP family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The NANP protein also known as NANP repeat exhibits a repeating structure found in the circumsporozoite protein of Plasmodium falciparum. It weighs approximately 45 kDa. This protein is specifically expressed on the surface of the sporozoite stage of the malaria parasite. The NANP sequence plays a critical role in the sporozoite's ability to interact with the surrounding environment and aids its mobility and infection process within the host.
- Biological function summary
The NANP repeat sequence is integral to the structural framework of the circumsporozoite protein. The circumsporozoite protein forms a protective coat around the sporozoite contributing to its survival and infectivity. The repetitive nature of the NANP sequence serves as a repetitive immunological target for antibodies making it a focus for vaccine development. Although it does not form a stable complex with other proteins its structural motif facilitates the parasite's ability to evade the host immune response during initial infection stages.
- Pathways
The NANP repeat significantly impacts the malaria infection process in humans. It participates in the invasion pathway aiding Plasmodium falciparum's entry into liver cells. This protein is related to proteins like merozoite surface protein 1 (MSP1) which is involved during subsequent stages of malaria infection. Understanding NANP's role helps researchers trace its involvement in the lifecycle progression of the parasite and its development inside the host.
- Associated diseases and disorders
The NANP sequence is closely associated with malaria pathogenesis. Its presence as an antigenic determinant implicates it in potential vaccine targets against malaria. Researchers have noted that NANP's interaction with human antibodies forms a critical part of immune evasion strategies used by the parasite. Proteins like antigens EBA175 associated with erythrocyte invasion are also important in understanding the broader implications of NANP in the persistence and severity of Plasmodium falciparum infections.
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SDS-PAGE - Recombinant Human NANP protein (ab99392)
15% SDS-PAGE analysis of 3μg ab99392.
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