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AB113164

Recombinant Human NAPG protein

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Recombinant Human NAPG protein is a Human Full Length protein, in the 1 to 312 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SNAPG, NAPG, Gamma-soluble NSF attachment protein, SNAP-gamma, N-ethylmaleimide-sensitive factor attachment protein gamma

1 Images
SDS-PAGE - Recombinant Human NAPG protein (AB113164)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NAPG protein (AB113164)

ab113164 at 3 µg analysed by 15% SDS PAGE.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q99747

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMAAQKINEGLEHLAKAEKYLKTGFLKWKPDYDSAASEYGKAAVAFKNAKQFEQAKDACLREAVAHENNRALFHAAKAYEQAGMMLKEMQKLPEAVQLIEKASMMYLENGTPDTAAMALERAGKLIENVDPEKAVQLYQQTANVFENEERLRQAVELLGKASRLLVRGRRFDEAALSIQKEKNIYKEIENYPTCYKKTIAQVLVHLHRNDYVAAERCVRESYSIPGFNGSEDCAALEQLLEGYDQQDQDQVSDVCNSPLFKYMDNDYAKLGLSLVVPGGGIKKKSPATPQAKPDGVTATAADEEEDEYSGGLC","proteinLength":"Full Length","predictedMolecularWeight":"37.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":312,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99747","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NAPG also known as N-ethylmaleimide-sensitive factor attachment protein gamma plays an important role in intracellular membrane fusion processes. It facilitates vesicular trafficking by interacting with the SNARE complex. NAPG has a molecular mass of approximately 33 kDa. This protein expresses widely in various tissues with higher levels noted in brain tissue suggesting an important role in neural processes.
Biological function summary

The function of NAPG relates to the mediation of vesicle transport within cells. It forms a part of the SNARE complex which is important for the fusion of transport vesicles with their target membranes. Through its action NAPG ensures the correct delivery of proteins and other molecules to their intended cellular compartments which is essential for maintaining cellular homeostasis and proper signal transduction.

Pathways

NAPG integrates into the SNARE-mediated membrane fusion pathway. This pathway is vital for synaptic vesicle exocytosis and intracellular trafficking across many cell types. NAPG works closely with other SNARE proteins like SNAP-25 and VAMP to ensure the efficiency and precision of vesicular transport and neurotransmitter release.

NAPG has associations with neurodegenerative diseases and disorders involving synaptic dysfunctions. Disruption of NAPG function or expression can lead to impaired neurotransmitter release contributing to conditions such as Alzheimer's disease. Additionally its interaction with proteins like alpha-synuclein highlights its involvement in diseases such as Parkinson's disease where vesicle trafficking is disrupted affecting neuronal communication.
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Specifications

Form

Liquid

Additional notes

ab113164 was purified by using conventional chromatography

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General info

Function

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Sequence similarities

Belongs to the SNAP family.

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Product protocols

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Target data

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
See full target information NAPG
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Product promise

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