Recombinant Human NARG1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NARG1 also known as NARGG or NMDA receptor-regulated gene protein 1 is a protein with a molecular mass of approximately 152 kDa. NARG1 directly participates in protein acetylation by transferring acetyl groups to lysine residues an important post-translational modification affecting protein function and interactions. This protein is expressed across various tissues with notable presence in the brain heart and testis indicating its diverse functional roles within different physiological contexts.

Biological function summary

The acetyltransferase activity of NARG1 significantly impacts gene regulation and cellular homeostasis. It forms part of the NatA complex where it functions together with other components such as NAA10 and NAA15. This complex plays a role in co-translational N-terminal acetylation influencing protein stability and function. NARG1's activity particulary affects processes like cell cycle progression apoptosis and cellular differentiation reflecting its importance in maintaining cellular balance.

Pathways

NARG1 activity links prominently to the signaling pathway of mRNA translation which is essential for protein synthesis and cellular growth. Additionally it participates in the regulation of apoptosis pathways modulating cell survival in response to various stress signals. Proteins like p53 and BCL-2 show interactions with these pathways revealing how NARG1 may influence key cellular outcomes and decision points regarding survival and death.

Studies have connected NARG1 to neural development and certain neurodegenerative conditions. Aberrations in NARG1 expression or function may contribute to disorders like Alzheimer’s Disease potentially affecting neuronal survival and cognitive function. The protein's role is also noteworthy in the context of cardiac hypertrophy where its regulatory capacity on cellular growth pathways can impact heart muscle function. Related proteins affected by these conditions may include components like tau in neurodegeneration and myosin heavy chain in cardiac pathophysiology.