Recombinant Human NARG1 protein is a Human Fragment protein, in the 764 to 862 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
H R L S A A K M V Y Y L D P S S Q K R A I E L A T T L D E S L T N R N L Q T C M E V L E A L Y D G S L G D C K E A A E I Y R A N C H K L F P Y A L A F M P P G Y E E D M K I T V N G D S S A E A E E L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306).
Alternative names
GA19, NARG1, NATH, TBDN100, NAA15, Gastric cancer antigen Ga19, N-terminal acetyltransferase, NMDA receptor-regulated protein 1, Protein tubedown-1, Tbdn100
Recommended products
Recombinant Human NARG1 protein is a Human Fragment protein, in the 764 to 862 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9BXJ9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- H R L S A A K M V Y Y L D P S S Q K R A I E L A T T L D E S L T N R N L Q T C M E V L E A L Y D G S L G D C K E A A E I Y R A N C H K L F P Y A L A F M P P G Y E E D M K I T V N G D S S A E A E E L
- Accession
- Q9BXJ9
- Protein length
- Fragment
- Amino acids
- 764 to 862
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306).
- Post-translational modifications
Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NARG1 also known as NARGG or NMDA receptor-regulated gene protein 1 is a protein with a molecular mass of approximately 152 kDa. NARG1 directly participates in protein acetylation by transferring acetyl groups to lysine residues an important post-translational modification affecting protein function and interactions. This protein is expressed across various tissues with notable presence in the brain heart and testis indicating its diverse functional roles within different physiological contexts.
- Biological function summary
The acetyltransferase activity of NARG1 significantly impacts gene regulation and cellular homeostasis. It forms part of the NatA complex where it functions together with other components such as NAA10 and NAA15. This complex plays a role in co-translational N-terminal acetylation influencing protein stability and function. NARG1's activity particulary affects processes like cell cycle progression apoptosis and cellular differentiation reflecting its importance in maintaining cellular balance.
- Pathways
NARG1 activity links prominently to the signaling pathway of mRNA translation which is essential for protein synthesis and cellular growth. Additionally it participates in the regulation of apoptosis pathways modulating cell survival in response to various stress signals. Proteins like p53 and BCL-2 show interactions with these pathways revealing how NARG1 may influence key cellular outcomes and decision points regarding survival and death.
- Associated diseases and disorders
Studies have connected NARG1 to neural development and certain neurodegenerative conditions. Aberrations in NARG1 expression or function may contribute to disorders like Alzheimer’s Disease potentially affecting neuronal survival and cognitive function. The protein's role is also noteworthy in the context of cardiac hypertrophy where its regulatory capacity on cellular growth pathways can impact heart muscle function. Related proteins affected by these conditions may include components like tau in neurodegeneration and myosin heavy chain in cardiac pathophysiology.
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1 product image
SDS-PAGE - Recombinant Human NARG1 protein (ab164208)
ab164208 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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