Recombinant Human NAT13 protein (His tag N-Terminus)
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Recombinant Human NAT13 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 169 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
MAK3, NAT13, NAT5, NAA50, N-alpha-acetyltransferase 50, hNaa50p, N-acetyltransferase 13, N-acetyltransferase 5, N-acetyltransferase san homolog, N-epsilon-acetyltransferase 50, NatE catalytic subunit, hNAT5, hSAN
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human NAT13 protein (His tag N-Terminus) (AB123145)
15% SDS PAGE, 3 µg of ab123145 loaded.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NAT13 exerts its effects on cellular growth modulation and proliferation. NAT13 functions as a part of the enzyme complexes that regulate the acetylation process modifying substrates in the cell. This modification impacts protein function stability and interaction with other cellular components. NAT13's enzymatic activity influences cell cycle regulation and is critical for normal cell growth and division.
Pathways
NAT13 influences polyamine biosynthesis and metabolism which are necessary for cell replication and growth. One of the significant pathways involving NAT13 is the spermidine and spermine biosynthesis pathway which interacts with the polyamine oxidase enzyme. These interactions help to balance cellular growth signals and maintain cellular homeostasis. Another associated pathway is histone acetylation impacting gene expression regulation and being correlated with the GCN5 protein.
Specifications
Form
Liquid
Additional notes
ab123145 was purified using conventional chromatography.
General info
Function
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed : 19744929, PubMed : 21900231, PubMed : 22311970, PubMed : 27484799). Has a broad substrate specificity : able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed : 27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed : 19744929). Autoacetylates in vivo (PubMed : 19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear : able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed : 19744929). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (PubMed : 16507339, PubMed : 27484799, PubMed : 29754825, PubMed : 32042062). Does not influence the acetyltransferase activity of NAA10 (PubMed : 16507339, PubMed : 27484799). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (PubMed : 32042062). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed : 16507339, PubMed : 27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin : may act by counteracting the function of NAA10 (PubMed : 17502424, PubMed : 27422821).
Sequence similarities
Belongs to the acetyltransferase family. GNAT subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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