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AB162880

Recombinant Human NCAPG2 protein (GST tag N-Terminus)

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Recombinant Human NCAPG2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 935 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

LUZP5, NCAPG2, Condensin-2 complex subunit G2, Chromosome-associated protein G2, Leucine zipper protein 5, Non-SMC condensin II complex subunit G2, CAP-G2, hCAP-G2

1 Images
SDS-PAGE - Recombinant Human NCAPG2 protein (GST tag N-Terminus) (AB162880)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human NCAPG2 protein (GST tag N-Terminus) (AB162880)

ab162880 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q86XI2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Primary Antibodies

AB70350

Anti-NCAPG2 antibody

Immunoprecipitation - Anti-NCAPG2 antibody (AB70350)

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Recombinant Human VNN3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VNN3 protein (GST tag N-Terminus) (AB163077)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLLECFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQKKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPNLHAIEMDSEIQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILIDLLKKVTGELAFDTSSADVRCSVFKCLPMILDNKLSHPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVRAAKFWKICPMEHILVRLETDSRPVSRRLVSLIFNSFLPVNQPEEVWCERCVTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSVNDVACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCSWGQVGHILELVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKPELALVYIEYLLTHPKNRECLLSAPRKKLNHLLKALETSKADLESLLQTPGGKPRGFSEAAAPRAFGLHCRLSIHLQHKFCSEGKVYLSMLEDTGFWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKDVVMVGLGDHQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSSLIQKTDSDEEVAMLLDTVQKVFQKMLECIARSFRKQPEEGLRLLYSVQRPLHEFITAVQSRHTDTPVHRGVLSTLIAGPVVEISHQLRKVSDVEELTPPEHLSDLPPFSRCLIGIIIKSSNVVRSFLDELKACVASNDIEGIVCLTAAVHIILVINAGKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGELLNS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":935,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q86XI2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein NCAPG2 also known as Condensin-2 complex subunit G2 is important to the mechanical processes within cells. It plays an important role in mitosis and is part of the condensin II complex responsible for chromosome condensation and stabilization during cell division. NCAPG2 is a large protein with a mass of around 120 kDa. Expression is predominantly observed in proliferating tissues such as those in the bone marrow and thymus. This wide expression reveals its direct participation in fundamental cellular functions.
Biological function summary

The organism relies on NCAPG2 to ensure accurate chromosome segregation. As a component of the condensin II complex it collaborates with other subunits including NCAPD3 and SMC2. The protein's main task is to maintain the structural integrity of chromosomes allowing proper chromosome alignment during mitosis. This integrity is essential for genomic stability reducing the risks of aneuploidy.

Pathways

NCAPG2 is deeply involved in the regulation of the cell cycle. It takes part in both the mitotic prophase and anaphase pathways. Its function relates closely to other proteins like Cdc2 and Cyclin B which direct the progression of cell division. By integrating with structural pathways of chromosomes NCAPG2 becomes an important element in preventing mitotic errors and preserving cellular fidelity.

NCAPG2 has been linked to carcinogenesis and some developmental disorders. Aberrant expression or dysfunction of NCAPG2 is often observed in certain cancers such as breast and prostate cancer where genomic instability is a common characteristic. In cancerous conditions its interaction with proteins like p53—known for DNA damage response—becomes significant highlighting its potential role in tumorigenesis. Furthermore studies investigate its connection with developmental anomalies probing possible implications in aberrant cellular proliferation pathways.
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Specifications

Form

Liquid

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General info

Function

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
See full target information NCAPG2
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