Recombinant Human NDP protein (denatured) (His tag N-Terminus)
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Recombinant Human NDP protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 25 to 133 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.
View Alternative Names
EVR2, NDP, Norrin, Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human NDP protein (denatured) (His tag N-Terminus) (AB171607)
SDS-PAGE analysis of Recombinant Human NDP protein (denatured) (ab171607), under reducing conditions. Proteins visualized by coomassie blue stain.
Lane 1 : Molecular Weight Standards
Lane 2 : 3 μg Recombinant Human NDP protein (denatured)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NDP acts as a ligand that associates with the Frizzled-4 receptor and LRP5/6 to activate the Wnt/β-catenin signaling pathway. This activation leads to a variety of cellular responses such as cell proliferation and differentiation which are essential in vascular development. NDP exists within a complex that includes other Wnt pathway components ensuring precise regulation of these biological processes.
Pathways
The involvement of NDP in the Wnt/β-catenin signaling is significant for its regulation of vascular development and maintenance. It interacts with LRP5/6 and Frizzled-4 proteins within this pathway ensuring that endothelial cells form proper blood vessel structures. NDP also has implications within angiogenesis another vital pathway for the growth of new blood vessels enhancing the understanding of its function in vascular biology.
Specifications
Form
Liquid
General info
Function
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Target data
Complementary Products
Product promise
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