Recombinant Human NDUFA2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NDUFA2 protein also known as NADH:Ubiquinone Oxidoreductase Subunit A2 is a component of the mitochondrial respiratory chain complex I. It has a mass of approximately 10.3 kDa. NDUFA2 is expressed in various tissues with high energy demands especially in the heart brain and skeletal muscles. Functionally it participates in the initial phase of electron transport by transferring electrons from NADH to ubiquinone contributing to the proton gradient used in ATP synthesis.

Biological function summary

NDUFA2 is a component of the multi-subunit complex I of the mitochondrial electron transport chain. This complex plays a role in cellular respiration by facilitating the conversion of energy stored in nutrients into ATP. Within the structure of complex I NDUFA2 collaborates with other subunits to ensure efficient electron transfer processes. Although a smaller subunit its role in the proper assembly and maintenance of the complex is essential for sustaining cellular energy levels.

Pathways

The actions of NDUFA2 are critical in oxidative phosphorylation one of the main pathways for ATP production in eukaryotic cells. This energy production pathway is intertwined with cellular respiration where NDUFA2 is related to proteins such as ND1 and ND2. These proteins collectively engage in the transfer of electrons across the inner mitochondrial membrane driving the synthesis of ATP from ADP through chemiosmotic coupling.

Alterations in NDUFA2 have connections to mitochondrial encephalomyopathy and Leigh Syndrome. These conditions manifest due to dysfunctional energy metabolism caused by defects in NDUFA2 and other proteins like NDUFS1. Mutations in these proteins can lead to impaired oxidative phosphorylation resulting in energy deficiencies that contribute to the development of neurodegenerative and muscular impairments seen in these disorders.