Recombinant Human NDUFA5 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NDUFA5 also known as NADH:Ubiquinone Oxidoreductase Subunit A5 is part of the mitochondrial respiratory chain complex I. This protein has an approximate molecular mass of 15 kDa. NDUFA5 is expressed in many tissues but shows higher levels in energy-demanding organs such as the heart brain and skeletal muscle. It contributes to cellular respiration by assisting in electron transfer from NADH to ubiquinone which is critical in energy production.

Biological function summary

NDUFA5 is an essential component of Complex I in the mitochondrial inner membrane. Complex I the largest enzyme complex of the mitochondrial electron transport chain consists of 45 subunits. NDUFA5 functions by aiding electron transfer through this complex. Proper function of NDUFA5 is vital for ATP generation through oxidative phosphorylation an important process in bioenergetics.

Pathways

The role of NDUFA5 in the electron transport chain places it central to the oxidative phosphorylation pathway. This pathway also includes other complexes such as Complex III and IV which continue electron transfer leading to ATP synthesis. NDUFA5 interacts closely with other subunits within Complex I like NDUFS2 and forms a luminal proton gradient necessary for ATP production.

NDUFA5 mutations have links to mitochondrial Complex I deficiency a condition causing disorders in energy metabolism. This deficiency can lead to a wide range of clinical manifestations including Leigh syndrome a severe neurological disorder. NDUFA5 dysfunction affects energy-intensive tissues and its abnormal activity could involve other proteins in Complex I such as NDUFS4 which together contribute to the pathology of these mitochondrial disorders.