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AB177596

Recombinant Human NDUFS5 protein (denatured) (His tag N-Terminus)

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Recombinant Human NDUFS5 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 106 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, Complex I-15 kDa, NADH-ubiquinone oxidoreductase 15 kDa subunit, CI-15 kDa, NDUFS5

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SDS-PAGE - Recombinant Human NDUFS5 protein (denatured) (His tag N-Terminus) (AB177596)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NDUFS5 protein (denatured) (His tag N-Terminus) (AB177596)

15% SDS-PAGE analysis of 3μg ab177596.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O43920

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris-HCl buffer

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP","proteinLength":"Full Length","predictedMolecularWeight":"14.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":106,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O43920","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NDUFS5 also known as NADH:Ubiquinone Oxidoreductase Subunit S5 forms a part of the mitochondrial complex I. This protein has a molecular mass of approximately 18 kDa. NDUFS5 is expressed in cells across various tissues including high levels in muscle tissues and neurons. The protein assists in the initial stages of the electron transport chain an essential process for cellular respiration and ATP production.
Biological function summary

NDUFS5 contributes to the electron transfer chain by participating in complex I. Complex I plays a central role in converting NADH to NAD+ facilitating the transport of electrons to ubiquinone. NDUFS5 is not a catalytic subunit but supports the overall structure and function of the complex working together with other subunits to maintain the electron flow essential for ATP synthesis.

Pathways

NDUFS5 actively participates in the oxidative phosphorylation pathway. This pathway drives the production of ATP the primary energy source for cells. NDUFS5 collaborates with other proteins like NDUFS2 and NDUFV1 in complex I of the electron transport chain. Additionally NDUFS5 contributes to pathways related to reactive oxygen species (ROS) production influencing cellular stress responses.

NDUFS5 is linked to mitochondrial dysfunctions including Leigh syndrome and mitochondrial encephalomyopathy. These conditions arise from defects in complex I in which NDUFS5 and proteins like MT-ND1 and NDUFS4 are involved. Such disruptions lead to impaired ATP production and increased oxidative stress affecting energy-intensive tissues like the brain and muscles.
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Specifications

Form

Liquid

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General info

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Sequence similarities

Belongs to the complex I NDUFS5 subunit family.

Subcellular localisation

Mitochondrion inner membrane

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Product protocols

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Target data

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
See full target information NDUFS5
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