Recombinant Human NDUFV3 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NDUFV3 also known as NADH:Ubiquinone Oxidoreductase Subunit V3 is integral to the electron transport chain in mitochondria. It weighs approximately 11 kDa and is found primarily in tissues with high energy demands such as the heart and skeletal muscle. This protein is a component of the mitochondrial complex I which is responsible for transferring electrons from NADH to ubiquinone while pumping protons across the inner mitochondrial membrane.

Biological function summary

NDUFV3 plays a role in cellular respiration and is a part of mitochondrial complex I. This complex is the largest of the five enzyme complexes involved in oxidative phosphorylation. NDUFV3 contributes to the initial step of the electron transfer process which is essential for ATP production in cells. The protein interacts with various subunits within the complex to ensure proper function and maintenance of energy production.

Pathways

NDUFV3 participates significantly in oxidative phosphorylation and the NAD+ metabolism pathways. It helps facilitate the electron flow important for the synthesis of ATP connecting it to other proteins like NDUFS2 within complex I. This function allows cells to convert biochemical energy from nutrients efficiently affecting cellular processes tied to energy production and utilization.

Malfunction of NDUFV3 can relate to mitochondrial diseases such as Leigh syndrome and Parkinson’s disease. Mutations or dysregulation in this protein affect the electron transport chain's efficiency leading to impaired energy production. This impact can ripple through associated proteins like NDUFA1 altering their function and contributing to disease pathology. Understanding NDUFV3's role in these disorders can provide valuable insights into potential therapeutic targets.