JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276370

Recombinant Human NECL-1 protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human NECL-1 protein (His tag) is a Human Fragment protein, in the 1 to 330 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

IGSF4B, NECL1, SYNCAM3, TSLL1, UNQ225/PRO258, CADM3, Cell adhesion molecule 3, Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, Nectin-like protein 1, Synaptic cell adhesion molecule 3, TSLC1-like protein 1, IgSF4B, NECL-1, SynCAM3

1 Images
SDS-PAGE - Recombinant Human NECL-1 protein (His tag) (AB276370)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NECL-1 protein (His tag) (AB276370)

SDS-PAGE analysis of ab276370

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8N126

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSSTYH","proteinLength":"Fragment","predictedMolecularWeight":"35.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":330,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8N126","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NECL-1 also known as Nectin-like protein 1 or SynCAM1 is a member of the immunoglobulin superfamily (IgSF). NECL-1 exhibits a molecular mass of approximately 48-60 kDa. This protein exists in neural tissues displaying abundant expression in the central nervous system. NECL-1 contributes to the formation and maintenance of cell-cell adhesion important for the integrity and architecture of neural networks. Beyond the brain scientists also report its presence in other tissues like the testes and lungs.
Biological function summary

NECL-1 facilitates the establishment of synapses and neuronal communication by interacting with other cell adhesion molecules. This protein functions as part of larger macromolecular complexes that include other nectin-like proteins ensuring robust signaling pathways and cellular interactions. In synaptic strength and plasticity NECL-1 raises interest for its role in regulating the adhesion between neurons an essential process for effective neural circuit formation and function.

Pathways

NECL-1 participates in pathways concerning axon guidance and synapse organization. One key pathway is the Nectin-related pathway where its interactions with members like NECL-2 (SynCAM 2) play a part. Another is the synaptic adhesion molecule pathway contributing to synaptogenesis. These pathways position NECL-1 as a significant player in neural development and synaptic function often coordinating with proteins like N-cadherin to influence neuronal migration and positioning.

NECL-1 has associations with neurological disorders such as schizophrenia and epilepsy. In schizophrenia dysregulation of synaptic proteins including NECL-1 may interrupt normal synaptic connectivity further connecting it to proteins like NLGN1 involved in synaptic stability. In epilepsy altered expression levels of NECL-1 could impact synaptic transmission affecting associated proteins such as neurexins which work to maintain synaptic balance and control. Understanding these connections offers potential therapeutic targets in managing these conditions.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).

Sequence similarities

Belongs to the nectin family.

style
left-column

Product protocols

style
left-column

Target data

Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).
See full target information CADM3
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB259412

Recombinant human VEGF 165A protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human VEGF 165A protein (Active) (AB259412)

  • 0
  • 0
Proteins & Peptides

AB269130

Recombinant human VCP protein (Active)

Functional Studies - Recombinant human VCP protein (Active) (AB269130)

  • 0
  • 0
Proteins & Peptides

AB269124

Recombinant human USP5 protein (Active)

Functional Studies - Recombinant human USP5 protein (Active) (AB269124)

  • 0
  • 0
Proteins & Peptides

AB163782

Recombinant Human VISTA protein

SDS-PAGE - Recombinant Human VISTA protein (AB163782)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com