Recombinant Human Nectin-4 protein is a Human Full Length protein, in the 1 to 510 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M P L S L G A E M W G P E A W L L L L L L L A S F T G R C P A G E L E T S D V V T V V L G Q D A K L P C F Y R G D S G E Q V G Q V A W A R V D A G E G A Q E L A L L H S K Y G L H V S P A Y E G R V E Q P P P P R N P L D G S V L L R N A V Q A D E G E Y E C R V S T F P A G S F Q A R L R L R V L V P P L P S L N P G P A L E E G Q G L T L A A S C T A E G S P A P S V T W D T E V K G T T S S R S F K H S R S A A V T S E F H L V P S R S M N G Q P L T C V V S H P G L L Q D Q R I T H I L H V S F L A E A S V R G L E D Q N L W H I G R E G A M L K C L S E G Q P P P S Y N W T R L D G P L P S G V R V D G D T L G F P P L T T E H S G I Y V C H V S N E F S S R D S Q V T V D V L D P Q E D S G K Q V D L V S A S V V V V G V I A A L L F C L L V V V V V L M S R Y H R R K A Q Q M T Q K Y E E E L T L T R E N S I R R L H S H H T D P R S Q P E E S V G L R A E G H P D S L K D N S S C S V M S E E P E G R S Y S T L T T V R E I E T Q T E L L S P G S G R A E E E E D Q D E G I K Q A M N H F V Q E N G T L R A K P T G N G I Y I N G R G H L V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.
Alternative names
LNIR, PRR4, PVRL4, NECTIN4, Nectin-4, Ig superfamily receptor LNIR, Nectin cell adhesion molecule 4, Poliovirus receptor-related protein 4
Recommended products
Recombinant Human Nectin-4 protein is a Human Full Length protein, in the 1 to 510 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q96NY8-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M P L S L G A E M W G P E A W L L L L L L L A S F T G R C P A G E L E T S D V V T V V L G Q D A K L P C F Y R G D S G E Q V G Q V A W A R V D A G E G A Q E L A L L H S K Y G L H V S P A Y E G R V E Q P P P P R N P L D G S V L L R N A V Q A D E G E Y E C R V S T F P A G S F Q A R L R L R V L V P P L P S L N P G P A L E E G Q G L T L A A S C T A E G S P A P S V T W D T E V K G T T S S R S F K H S R S A A V T S E F H L V P S R S M N G Q P L T C V V S H P G L L Q D Q R I T H I L H V S F L A E A S V R G L E D Q N L W H I G R E G A M L K C L S E G Q P P P S Y N W T R L D G P L P S G V R V D G D T L G F P P L T T E H S G I Y V C H V S N E F S S R D S Q V T V D V L D P Q E D S G K Q V D L V S A S V V V V G V I A A L L F C L L V V V V V L M S R Y H R R K A Q Q M T Q K Y E E E L T L T R E N S I R R L H S H H T D P R S Q P E E S V G L R A E G H P D S L K D N S S C S V M S E E P E G R S Y S T L T T V R E I E T Q T E L L S P G S G R A E E E E D Q D E G I K Q A M N H F V Q E N G T L R A K P T G N G I Y I N G R G H L V
- Accession
- Q96NY8
- Protein length
- Full Length
- Amino acids
- 1 to 510
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.
- Sequence similarities
Belongs to the nectin family.
- Post-translational modifications
The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Nectin-4 also known as PVRL4 is a member of the immunoglobulin-like adhesion molecule family. It has a molecular weight of approximately 66 kDa. Nectin-4 plays an important role in cell-cell adhesion by forming trans-dimers promoting cellular cohesion. It is expressed in tissues such as placenta embryonic tissues and several epithelial cancers indicating its potential involvement in developmental processes and pathological conditions. When utilizing methods such as 'nectin-4 ELISA' and 'nectin-4 IHC' researchers can study its expression extensively across different tissue samples.
- Biological function summary
Nectin-4 functions as an important adhesion molecule that contributes to the maintenance and organization of cell junctions. It is often part of larger adhesive complexes that include afadin which links nectin proteins to the actin cytoskeleton stabilizing cell structure. Besides its role in maintaining cell-cell adhesion nectin-4 is significant in processes like cellular polarization and migration. These properties make it an important target for understanding tissue development and integrity as well as cancer metastasis.
- Pathways
Nectin-4 belongs to the pathways regulating cell adhesion and the cytoskeletal organization. It is closely associated with the cadherin and integrin signaling pathways where it collaborates with other nectin family members and afadin to regulate these networks. These interactions impact cellular processes such as signal transduction and intercellular communication critical for tissue maintenance. Studies involving 'nectin expression' help further elucidate these pathway connections and their implications in healthy and diseased tissues.
- Associated diseases and disorders
Nectin-4 shows significant correlation with certain cancers such as breast and lung carcinoma. Its elevated expression in tumor tissues suggests a role in tumorigenesis and cancer progression. The protein's interaction with oncogenes like HER2 indicates a possible pathway by which nectin-4 affects cancer cell proliferation and survival. Understanding 'nectin-4 expression' in the context of these diseases aids in identifying potential biomarkers and therapeutic targets for cancer diagnosis and treatment.
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1 product image
SDS-PAGE - Recombinant Human Nectin-4 protein (ab164347)
ab164347 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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