Recombinant Human NEGR1 protein (His tag) is a Human Fragment protein, in the 1 to 324 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M D M M L L V Q G A C C S N Q W L A A V L L S L C C L L P S C L P A G Q S V D F P W A A V D N M M V R K G D T A V L R C Y L E D G A S K G A W L N R S S I I F A G G D K W S V D P R V S I S T L N K R D Y S L Q I Q N V D V T D D G P Y T C S V Q T Q H T P R T M Q V H L T V Q V P P K I Y D I S N D M T V N E G T N V T L T C L A T G K P E P S I S W R H I S P S A K P F E N G Q Y L D I Y G I T R D Q A G E Y E C S A E N D V S F P D V R K V K V V V N F A P T I Q E I K S G T V T P G R S G L I R C E G A G V P P P A F E W Y K G E K K L F N G Q Q G I I I Q N F S T R S I L T V T N V T Q E H F G N Y T C V A A N K L G T T N A S L P L N P P S T A Q Y G I T G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
Alternative names
IGLON4, UNQ2433/PRO4993, NEGR1, Neuronal growth regulator 1, IgLON family member 4
Recommended products
Recombinant Human NEGR1 protein (His tag) is a Human Fragment protein, in the 1 to 324 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q7Z3B1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M D M M L L V Q G A C C S N Q W L A A V L L S L C C L L P S C L P A G Q S V D F P W A A V D N M M V R K G D T A V L R C Y L E D G A S K G A W L N R S S I I F A G G D K W S V D P R V S I S T L N K R D Y S L Q I Q N V D V T D D G P Y T C S V Q T Q H T P R T M Q V H L T V Q V P P K I Y D I S N D M T V N E G T N V T L T C L A T G K P E P S I S W R H I S P S A K P F E N G Q Y L D I Y G I T R D Q A G E Y E C S A E N D V S F P D V R K V K V V V N F A P T I Q E I K S G T V T P G R S G L I R C E G A G V P P P A F E W Y K G E K K L F N G Q Q G I I I Q N F S T R S I L T V T N V T Q E H F G N Y T C V A A N K L G T T N A S L P L N P P S T A Q Y G I T G
- Accession
- Q7Z3B1
- Protein length
- Fragment
- Predicted molecular weight
- 32.9 kDa
- Amino acids
- 1 to 324
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
- Sequence similarities
Belongs to the immunoglobulin superfamily. IgLON family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
NEGR1 also known as Neuronal Growth Regulator 1 is a protein that plays an essential role in cellular adhesion and neurodevelopment. It carries a molecular mass of approximately 29 kDa. This protein shows expression mainly in the human brain particularly in regions such as the cortex and cerebellum. Studies have also detected NEGR1 in peripheral tissues to a lesser extent indicating a possible broader range of functions.
- Biological function summary
NEGR1 contributes to neuronal growth and connectivity. It forms part of the immunoglobulin superfamily which includes proteins involved in the immune response and cell adhesion processes. NEGR1 interacts with cellular membranes through a glycosylphosphatidylinositol anchor facilitating cell-cell communication and signaling necessary for neural network formation. This interaction allows NEGR1 to be a part of synaptic development and plasticity affecting learning and memory processes.
- Pathways
NEGR1 plays a part in neuronal growth pathways and synaptic signaling. These pathways are important for the development and maintenance of neuronal circuits. NEGR1 has connections to the MAPK pathway which oversees cell differentiation and proliferation. It interacts with other synaptic proteins like Neurexins and Neuroligins which are important for synaptic formation and stability underlining its integrative role in neural development.
- Associated diseases and disorders
NEGR1 has links to neurodevelopmental disorders and metabolic conditions. Research has identified associations between NEGR1 variants and autism spectrum disorders suggesting its impact on neural circuit wiring might influence these developmental conditions. Additionally NEGR1 appears related to obesity where it interacts with proteins like Leptin which regulates energy balance and body weight. These associations underline NEGR1's relevance in both neural and metabolic health.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human NEGR1 protein (His tag) (ab276365)
SDS-PAGE analysis of ab276365
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com