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AB276365

Recombinant Human NEGR1 protein (His tag)

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Recombinant Human NEGR1 protein (His tag) is a Human Fragment protein, in the 1 to 324 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

IGLON4, UNQ2433/PRO4993, NEGR1, Neuronal growth regulator 1, IgLON family member 4

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SDS-PAGE - Recombinant Human NEGR1 protein (His tag) (AB276365)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NEGR1 protein (His tag) (AB276365)

SDS-PAGE analysis of ab276365

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q7Z3B1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITG","proteinLength":"Fragment","predictedMolecularWeight":"32.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":324,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q7Z3B1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEGR1 also known as Neuronal Growth Regulator 1 is a protein that plays an essential role in cellular adhesion and neurodevelopment. It carries a molecular mass of approximately 29 kDa. This protein shows expression mainly in the human brain particularly in regions such as the cortex and cerebellum. Studies have also detected NEGR1 in peripheral tissues to a lesser extent indicating a possible broader range of functions.
Biological function summary

NEGR1 contributes to neuronal growth and connectivity. It forms part of the immunoglobulin superfamily which includes proteins involved in the immune response and cell adhesion processes. NEGR1 interacts with cellular membranes through a glycosylphosphatidylinositol anchor facilitating cell-cell communication and signaling necessary for neural network formation. This interaction allows NEGR1 to be a part of synaptic development and plasticity affecting learning and memory processes.

Pathways

NEGR1 plays a part in neuronal growth pathways and synaptic signaling. These pathways are important for the development and maintenance of neuronal circuits. NEGR1 has connections to the MAPK pathway which oversees cell differentiation and proliferation. It interacts with other synaptic proteins like Neurexins and Neuroligins which are important for synaptic formation and stability underlining its integrative role in neural development.

NEGR1 has links to neurodevelopmental disorders and metabolic conditions. Research has identified associations between NEGR1 variants and autism spectrum disorders suggesting its impact on neural circuit wiring might influence these developmental conditions. Additionally NEGR1 appears related to obesity where it interacts with proteins like Leptin which regulates energy balance and body weight. These associations underline NEGR1's relevance in both neural and metabolic health.
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Specifications

Form

Lyophilized

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General info

Function

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

Sequence similarities

Belongs to the immunoglobulin superfamily. IgLON family.

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Product protocols

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Target data

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
See full target information NEGR1
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Product promise

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