Recombinant human NEK11 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEK11 also known as NIMA-related kinase 11 acts as a serine/threonine-protein kinase with important roles in cell cycle regulation. The protein has an approximate mass of 76 kDa and shows expression in various tissues including high levels in testis and liver. NEK11 localizes mainly in the nucleus where it performs its functions in response to cellular stress particularly during DNA damage.

Biological function summary

NEK11 influences cell cycle control and integrates into mechanisms that manage DNA repair. It phosphorylates proteins involved in checkpoint regulation helping the cell respond to DNA damage. NEK11 does not operate alone but is part of a complex of proteins that ensure genomic stability under stress conditions. This complex role highlights its contribution to maintaining cell integrity.

Pathways

NEK11 integrates into DNA damage response pathways such as the ATM-ATR signaling pathway and the p53 pathway. These pathways are important for cell cycle arrest and repair. NEK11 interacts closely with proteins like CHK1 and CHK2 which are well-known for their roles in managing cellular responses to DNA damage and preserving genomic stability.

NEK11 connects to disorders involving genomic instability like cancer. Abnormal NEK11 expression or function disrupts cell cycle regulation contributing to tumorigenesis. It also shows ties to proteins like p53 a tumor suppressor that plays a central role in diagnosing and understanding cancers. NEK11’s involvement in these pathways makes it a relevant target for cancer research and therapy.