Recombinant human NEK3 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEK3 also known as serine/threonine-protein kinase Nek3 belongs to the NIMA-related kinase family. This protein kinase has a mass of approximately 60 kDa. It is expressed in various tissues with notable expression in the brain and mammary gland. NEK3 is a component of the cellular machinery that regulates cell cycle processes specifically the G2/M transition through its kinase activity impacting the spindle assembly and other processes.

Biological function summary

NEK3 plays a role in cell division and proliferation. It interacts with other cellular components to facilitate proper cell cycle progression. NEK3 does not function in isolation; it forms part of complexes with other proteins such as estrogen receptor-associated proteins. These interactions suggest that NEK3 has a role in steroid hormone signaling pathways.

Pathways

This protein kinase contributes to the regulation of the MAPK/ERK pathway and cell cycle checkpoint pathways. NEK3 modulates certain pathways by interacting with proteins like MAPK1 which help transmit signals for cell growth and differentiation. Its involvement in these pathways indicates that NEK3 serves as a link between external growth signals and internal cell cycle control mechanisms.

Research has implicated NEK3 in breast cancer and neurodevelopmental disorders. In breast cancer NEK3 expression levels may influence tumor progression by interacting with the estrogen receptor and kinases like MAPK1. The study of NEK3 in neurodevelopmental disorders associates it with abnormal brain development and function suggesting interactions with proteins involved in neural growth and signaling. These connections make NEK3 a target of interest for therapeutic research in these areas.