Recombinant human NEK5 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEK5 known as NIMA-related kinase 5 is a serine/threonine-protein kinase with a molecular mass of approximately 71 kDa. It plays a dynamic role in cell cycle regulation. NEK5 is part of the NEK family of kinases which are similar to Aspergillus nidulans NIMA. It is mainly expressed in testes bone marrow and certain types of muscle tissue. Its kinase activity is important for the mitotic process helping to control cell division.

Biological function summary

NEK5 participates in important steps of cell cycle progression by influencing cell cycle checkpoints. It does not belong to any well-characterized complex but its functional role in the cell cycle suggests interaction with other proteins during mitosis. Studies have shown that NEK5 can impact microtubule stabilization which affects proper chromosome segregation during cell division. This regulation is key to maintaining cellular integrity during proliferation.

Pathways

NEK5 acts within the cell cycle pathway particularly influencing the mitotic phase. It shares functional pathways with other NEK family members such as NEK2 and NEK7 which also have roles in cell cycle control. These kinases interact with microtubule-associated proteins ensuring correct spindle assembly and function. NEK5's activity in these pathways ensures genomic stability by controlling mitotic progression.

NEK5 has been linked to certain types of cancer due to its role in cell division. Aberrant expression or mutation can lead to unchecked cellular proliferation increasing cancer risk. It also has potential connections to neurodegenerative disorders given its expression in neural tissues although further research is needed in this area. NEK2 another kinase from the same family also shows similar cancer-related pathologies through dysregulation of mitotic processes.