Recombinant human NEK8 protein
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Recombinant human NEK8 protein is a Human Fragment protein, in the 1 to 322 aa range, expressed in Baculovirus infected Sf9 cells, with >75%, suitable for SDS-PAGE, FuncS.
View Alternative Names
JCK, NEK12A, NEK8, Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, Nima-related protein kinase 12a, NimA-related protein kinase 8
- FuncS
Supplier Data
Functional Studies - Recombinant human NEK8 protein (AB204141)
Sample Kinase Activity Plot showing ab204141. The specific activity of NEK8 was determined to be 5 nmol /min/mg as per activity assay protocol.
- FuncS
Unknown
Functional Studies - Recombinant human NEK8 protein (AB204141)
The specific activity of NEK8 (ab204141) was determined to be 1.8 nmol/min/mg as per activity assay protocol and was equivalent to 5 nmol/min/mg as per radiometric assay
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human NEK8 protein (AB204141)
SDS PAGE analysis of ab204141
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human NEK8 protein (AB204141)
SDS-PAGE showing ab204141.
Complementary Products
Reactivity data
Product details
Sequence info
Properties and storage information
Form
Purification technique
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NEK8 functions in the regulation of cilia length and stability. It integrates within a signaling complex at the ciliary transition zone important for ciliary function. NEK8 interacts with other components such as inversin and polycystin-2 essential for maintaining normal ciliary processes and signal transduction. Its role in ciliary dynamics suggests its importance to the proper cellular communication and organ development.
Pathways
NEK8 participates in the cilia-related signaling pathways and cell cycle regulation. It influences the Hedgehog signaling pathway which is vital for various developmental processes. NEK8 also interacts with proteins like Gli family transcription factors within this pathway. Another pathway involving NEK8 is the DNA damage response where it collaborates with proteins like ATR to maintain genomic stability.
General info
Function
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (PubMed : 37598857). Plays a role in organogenesis, and is involved in the regulation of the Hippo signaling pathway (PubMed : 26967905).
Sequence similarities
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Subcellular localisation
Cytoskeleton
Target data
Product promise
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