JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276405

Recombinant Human NETO1 protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human NETO1 protein (His tag) is a Human Fragment protein, in the 1 to 344 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

BTCL1, NETO1, Neuropilin and tolloid-like protein 1, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

1 Images
SDS-PAGE - Recombinant Human NETO1 protein (His tag) (AB276405)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NETO1 protein (His tag) (AB276405)

SDS-PAGE analysis of ab276405

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8TDF5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MIHGRSVLHIVASLIILHLSGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKTSLLDQLTNTSGT","proteinLength":"Fragment","predictedMolecularWeight":"38 kDa","actualMolecularWeight":null,"aminoAcidEnd":344,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8TDF5","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NETO1 protein also known as Neuropilin and Tolloid-like 1 is a transmembrane protein with a molecular weight of about 75 kDa. It is primarily expressed in the central nervous system particularly in the hippocampus and cerebellum. NETO1 serves as an auxiliary subunit of ionotropic glutamate receptors specifically the kainate receptor. It modulates the receptor's function by enhancing its kinetics and gating critical for synaptic transmission and plasticity.
Biological function summary

The protein interacts with kainate receptors forming a functional receptor complex that aids in neurotransmission processes. The complex plays a significant role in synaptic scaling and has implications for learning and memory functions. NETO1's ability to bind to various ligands on the glutamate receptor ensures its engagement in critical signal transduction activities across neuronal synapses.

Pathways

The function of NETO1 integrates into neurotransmission and synaptic plasticity pathways. NETO1 plays an important role in the glutamatergic synaptic transmission pathway alongside proteins like the GLUR5 receptor subunit. This involvement facilitates efficient communication between neurons influencing long-term potentiation and depression which are central to learning and memory processes.

NETO1's dysfunction associates with neurological and psychiatric conditions such as schizophrenia and epilepsy. Altered expression or mutations in NETO1 can impact the signaling pathway affecting synaptic strength and neuronal communication. It also interacts with proteins such as DLG4 also known as PSD-95 in these conditions further implicating NETO1 in the stability and function of postsynaptic densities potentially leading to cognitive and behavioral abnormalities.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

style
left-column

Product protocols

style
left-column

Target data

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
See full target information NETO1
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB183259

Recombinant Human TSR2 protein

SDS-PAGE - Recombinant Human TSR2 protein (AB183259)

  • 0
  • 0
Proteins & Peptides

AB276695

Recombinant Human TECTB protein (His tag)

SDS-PAGE - Recombinant Human TECTB protein (His tag) (AB276695)

  • 0
  • 0
Proteins & Peptides

AB276621

Recombinant Human TMIGD1 protein (His tag)

SDS-PAGE - Recombinant Human TMIGD1 protein (His tag) (AB276621)

  • 0
  • 0
Proteins & Peptides

AB181920

Recombinant Human TRBP protein (denatured)

SDS-PAGE - Recombinant Human TRBP protein (denatured) (AB181920)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com