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AB276476

Recombinant Human Netrin G1 protein (His tag)

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Recombinant Human Netrin G1 protein (His tag) is a Human Fragment protein, in the 1 to 408 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

KIAA0976, LMNT1, UNQ571/PRO1133, NTNG1, Netrin-G1, Laminet-1

1 Images
SDS-PAGE - Recombinant Human Netrin G1 protein (His tag) (AB276476)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Netrin G1 protein (His tag) (AB276476)

SDS-PAGE analysis of ab276476.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y2I2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Primary Antibodies

AB319038

Anti-Netrin G1 antibody [EPR27984-506] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Netrin G1 antibody [EPR27984-506] - BSA and Azide free (AB319038)

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Proteins & Peptides

AB156351

Recombinant Human Ephrin A3 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (His tag N-Terminus) (AB156351)

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Proteins & Peptides

AB114813

Recombinant Human RTR protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human RTR protein (GST tag N-Terminus) (AB114813)

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  • 0
Assay Kits

AB267631

Human HGFA ELISA Kit

Sandwich ELISA - Human HGFA ELISA Kit (AB267631)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MYLSRFLSIHALWVTVSSVMQPYPLVWGHYDLCKTQIYTEEGKVWDYMACQPESTDMTKYLKVKLDPPDITCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCNLHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIGTNVCDNELLHCQNGGTCHNNVRCLCPAAYTGILCEKLRCEEAGSCG","proteinLength":"Fragment","predictedMolecularWeight":"45.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":408,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9Y2I2","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Netrin G1 also known as Netrin-G1 or NTNG1 is a protein involved in axonal guidance. This protein helps in the development and differentiation of the central nervous system. It has a mass of approximately 64 kDa. Netrin G1 is expressed in brain regions such as the hippocampus and cerebral cortex. Unlike other netrins it is tethered to the membrane through a glycosylphosphatidylinositol (GPI) anchor affecting its signaling properties.
Biological function summary

Netrin G1 plays a significant role in neuronal circuit formation. It interacts with ligands like NGL1 and NGL2 to mediate cell signaling pathways that guide axonal growth and synapse formation. While it is not a part of a molecular complex on its own its association with these partners enhances its functionality in synaptic connectivity and neural network maintenance.

Pathways

Netrin G1 engages in the axon guidance pathway and is involved in nervous system development processes. It works alongside proteins such as Netrin-1 to influence the direction and growth of axons. Through these interactions Netrin G1 contributes to the precise wiring of the nervous system required for proper function. Understanding its role in these pathways provides insight into the molecular mechanisms of neural development.

Changes in Netrin G1 expression and function have been linked to neuropsychiatric conditions like schizophrenia and autism spectrum disorders. Studies suggest that Netrin G1 through its interaction with other proteins like Netrin-1 and DCC can alter synaptic connectivity which may play a role in the pathology of these conditions. These associations make Netrin G1 a potential target for therapeutic interventions in related neurological disorders.
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General info

Function

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
See full target information NTNG1
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Product promise

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