Recombinant Human Neurexin 1 protein (GST tag N-Terminus)
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(1 Publication)
Recombinant Human Neurexin 1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 31 to 130 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
KIAA0578, NRXN1, Neurexin-1, Neurexin I-alpha, Neurexin-1-alpha
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Neurexin 1 protein (GST tag N-Terminus) (AB160463)
ab160463 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Neurexin 1 participates in the assembly of trans-synaptic signaling complexes. It forms complexes with neuroligins which are postsynaptic cell adhesion proteins impacting synaptic specificity and connectivity. Through its interactions Neurexin 1 helps organize and regulate synaptic transmission influencing the efficiency and plasticity of synaptic connections. These processes are important for proper brain function impacting learning and memory retention.
Pathways
Neurexin 1 plays significant parts in neurotransmitter release mechanisms. It is involved in synaptic vesicle exocytosis pathway where it interacts with the presynaptic active zone components to influence neurotransmitter release. Additionally Neurexin 1 is linked to the glutamatergic synapse pathway where it interacts with neuroligins to modulate excitatory synaptic strength. These interactions ensure the balance of excitatory and inhibitory signals within neural networks.
Specifications
Form
Liquid
General info
Function
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
Sequence similarities
Belongs to the neurexin family.
Post-translational modifications
O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins and LRRTM2.
Target data
Publications (1)
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Stroke 46:2607-15 PubMed26219651
2015
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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