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AB171589

Recombinant Human NEURL2 protein (denatured)

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(1 Publication)

Recombinant Human NEURL2 protein (denatured) is a Human Full Length protein, in the 1 to 285 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

C20orf163, NEURL2, Neuralized-like protein 2

1 Images
SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (AB171589)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human NEURL2 protein (denatured) (AB171589)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BR09

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAASEPVDSGALWGLERPEPPPTRFHRVHGANIRVDPSGTRATRVESFAHGVCFSREPLAPGQVFLVEIEEKELGWCGHLRLGLTALDPASLAPVPEFSLPDLVNLGHTWVFAITRHHNRVPREGRPEAEAAAPSRPPTLLVEPYLRIEQFRIPRDRLVGRSRPGLYSHLLDQLYELNVLPPTARRSRLGVLFCPRPDGTADMHIIINGEDMGPSARGLPAAQPLYAVVDVFASTKSVRLVQLEYGLPSLQTLCRLVIQRSMVHRLAIDGLHLPKELKDFCKYE","proteinLength":"Full Length","predictedMolecularWeight":"34.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":285,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BR09","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NEURL2 also known as Neuralized E3 ubiquitin protein ligase 2 is an enzyme with a molecular mass of approximately 63 kDa. This protein functions mechanically as an E3 ubiquitin ligase facilitating the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins. NEURL2 aids in the regulation of protein degradation via the ubiquitin-proteasome system. Expression of NEURL2 is observed in neural tissues reflecting its role in the nervous system.
Biological function summary

NEURL2 plays a role in neuronal development and synaptic functions. It engages in the ubiquitination of proteins involved in synaptic plasticity and maintenance. NEURL2 does not typically form part of a larger complex but interacts directly with substrates and regulatory proteins. The activity of NEURL2 helps control protein levels within cells influencing cellular responses and function.

Pathways

NEURL2 participates in the Notch signaling pathway a pathway important for neurogenesis and cell differentiation. It interacts with and regulates proteins such as Delta and Notch receptors which are key players in this pathway. NEURL2's ubiquitin ligase activity modulates the availability and turnover of these proteins thereby impacting pathway dynamics and cellular outcomes.

NEURL2 has associations with neurological conditions. Disruption in its function can link to neurodevelopmental disorders such as autism spectrum disorder. NEURL2's interaction with Notch receptors and other substrates might influence aberrant signaling pathways in these disorders. Additionally there is some evidence suggesting its involvement in neurodegenerative diseases with interactions involving proteins like presenilin that could contribute to disease pathophysiology.
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Specifications

Form

Liquid

Additional notes

ab171589 was purified using conventional chromatography.

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General info

Function

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

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Product protocols

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Target data

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
See full target information NEURL2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 35:109125 PubMed33979606

2021

A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein.

Applications

Unspecified application

Species

Unspecified reactive species

Nikki M McCormack,Mahlet B Abera,Eveline S Arnold,Rebecca M Gibbs,Scott E Martin,Eugen Buehler,Yu-Chi Chen,Lu Chen,Kenneth H Fischbeck,Barrington G Burnett
View all publications
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