Recombinant Human Neurofascin protein (His tag) is a Human Fragment protein, in the 1 to 939 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A R Q P P P P W V H A A F L L C L L S L G G A I E I P M D P S I Q N E L T Q P P T I T K Q S A K D H I V D P R D N I L I E C E A K G N P A P S F H W T R N S R F F N I A K D P R V S M R R R S G T L V I D F R S G G R P E E Y E G E Y Q C F A R N K F G T A L S N R I R L Q V S K S P L W P K E N L D P V V V Q E G A P L T L Q C N P P P G L P S P V I F W M S S S M E P I T Q D K R V S Q G H N G D L Y F S N V M L Q D M Q T D Y S C N A R F H F T H T I Q Q K N P F T L K V L T T R G V A E R T P S F M Y P Q G T A S S Q M V L R G M D L L L E C I A S G V P T P D I A W Y K K G G D L P S D K A K F E N F N K A L R I T N V S E E D S G E Y F C L A S N K M G S I R H T I S V R V K A A P Y W L D E P K N L I L A P G E D G R L V C R A N G N P K P T V Q W M V N G E P L Q S A P P N P N R E V A G D T I I F R D T Q I S S R A V Y Q C N T S N E H G Y L L A N A F V S V L D V P P R M L S P R N Q L I R V I L Y N R T R L D C P F F G S P I P T L R W F K N G Q G S N L D G G N Y H V Y E N G S L E I K M I R K E D Q G I Y T C V A T N I L G K A E N Q V R L E V K D P T R I Y R M P E D Q V A R R G T T V Q L E C R V K H D P S L K L T V S W L K D D E P L Y I G N R M K K E D D S L T I F G V A E R D Q G S Y T C V A S T E L D Q D L A K A Y L T V L A D Q A T P T N R L A A L P K G R P D R P R D L E L T D L A E R S V R L T W I P G D A N N S P I T D Y V V Q F E E D Q F Q P G V W H D H S K Y P G S V N S A V L R L S P Y V N Y Q F R V I A I N E V G S S H P S L P S E R Y R T S G A P P E S N P G D V K G E G T R K N N M E I T W T P M N A T S A F G P N L R Y I V K W R R R E T R E A W N N V T V W G S R Y V V G Q T P V Y V P Y E I R V Q A E N D F G K G P E P E S V I G Y S G E D L P S A P R R F R V R Q P N L E T I N L E W D H P E H P N G I M I G Y T L K Y V A F N G T K V G K Q I V E N F S P N Q T K F T V Q R T D P V S R Y R F T L S A R T Q V G S G E A V T E E S P A P P N E A T P T A A Y T N N Q A D I A T Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
Alternative names
KIAA0756, NFASC, Neurofascin
Recommended products
Recombinant Human Neurofascin protein (His tag) is a Human Fragment protein, in the 1 to 939 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- O94856-12
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A R Q P P P P W V H A A F L L C L L S L G G A I E I P M D P S I Q N E L T Q P P T I T K Q S A K D H I V D P R D N I L I E C E A K G N P A P S F H W T R N S R F F N I A K D P R V S M R R R S G T L V I D F R S G G R P E E Y E G E Y Q C F A R N K F G T A L S N R I R L Q V S K S P L W P K E N L D P V V V Q E G A P L T L Q C N P P P G L P S P V I F W M S S S M E P I T Q D K R V S Q G H N G D L Y F S N V M L Q D M Q T D Y S C N A R F H F T H T I Q Q K N P F T L K V L T T R G V A E R T P S F M Y P Q G T A S S Q M V L R G M D L L L E C I A S G V P T P D I A W Y K K G G D L P S D K A K F E N F N K A L R I T N V S E E D S G E Y F C L A S N K M G S I R H T I S V R V K A A P Y W L D E P K N L I L A P G E D G R L V C R A N G N P K P T V Q W M V N G E P L Q S A P P N P N R E V A G D T I I F R D T Q I S S R A V Y Q C N T S N E H G Y L L A N A F V S V L D V P P R M L S P R N Q L I R V I L Y N R T R L D C P F F G S P I P T L R W F K N G Q G S N L D G G N Y H V Y E N G S L E I K M I R K E D Q G I Y T C V A T N I L G K A E N Q V R L E V K D P T R I Y R M P E D Q V A R R G T T V Q L E C R V K H D P S L K L T V S W L K D D E P L Y I G N R M K K E D D S L T I F G V A E R D Q G S Y T C V A S T E L D Q D L A K A Y L T V L A D Q A T P T N R L A A L P K G R P D R P R D L E L T D L A E R S V R L T W I P G D A N N S P I T D Y V V Q F E E D Q F Q P G V W H D H S K Y P G S V N S A V L R L S P Y V N Y Q F R V I A I N E V G S S H P S L P S E R Y R T S G A P P E S N P G D V K G E G T R K N N M E I T W T P M N A T S A F G P N L R Y I V K W R R R E T R E A W N N V T V W G S R Y V V G Q T P V Y V P Y E I R V Q A E N D F G K G P E P E S V I G Y S G E D L P S A P R R F R V R Q P N L E T I N L E W D H P E H P N G I M I G Y T L K Y V A F N G T K V G K Q I V E N F S P N Q T K F T V Q R T D P V S R Y R F T L S A R T Q V G S G E A V T E E S P A P P N E A T P T A A Y T N N Q A D I A T Q
- Accession
- O94856
- Protein length
- Fragment
- Predicted molecular weight
- 104.4 kDa
- Amino acids
- 1 to 939
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
- Sequence similarities
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Neurofascin also known as NFASC is a cell adhesion molecule with significant roles in the nervous system. It has various isoforms with Neurofascin-186 and Neurofascin-155 being the most studied. The molecular mass of Neurofascin is approximately 135 kDa. This protein is expressed in the nervous system particularly at nodes of Ranvier and paranodal regions as well as in the initial segment of axons. Neurofascin contributes to organizing and maintaining the axonal domains essential for neural signal transmission.
- Biological function summary
This neural protein plays an integral role in developing and securing the nervous system's structural organization. Neurofascin helps form the nodes of Ranvier which are critical for saltatory conduction enhancing rapid and efficient nerve impulse transmission. It also interacts with other proteins such as Ankyrin G and Contactin to maintain the stability and function of neuronal domains. Through these interactions Neurofascin facilitates the proper conduction and coordination of electrical signals along neurons.
- Pathways
Neurofascin is essential for neural signal transmission and maintenance pathways. It prominently participates in the axon guidance and myelination pathways working alongside proteins like Caspr (Contactin-associated protein) and Ankyrin B. These pathways ensure the growth and maintenance of myelin sheaths supporting nerve insulation and efficient signal relay. Neurofascin's interaction with these proteins reinforces the nodes of Ranvier's organization promoting stable and rapid signal conduction in the peripheral and central nervous systems.
- Associated diseases and disorders
Research links Neurofascin with autoimmune neuropathies like Guillain-Barré syndrome and multiple sclerosis. These conditions involve the immune-mediated destruction of myelin leading to severe motor and sensory deficits. Neurofascin acts as a target in some autoimmune responses where antibodies may mistakenly attack the protein disrupting neural conduction. Connections between Neurofascin and other proteins like Contactin and Ankyrin G highlight the complex interactions that can lead to pathological states when disrupted. Developing therapies targeting Neurofascin-related pathways holds potential for mitigating these disorders' impacts on neuronal functions.
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SDS-PAGE - Recombinant Human Neurofascin protein (His tag) (ab276683)
SDS-PAGE analysis of ab276683
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