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AB131781

Recombinant Human Neurogenin 2/NGN2 protein (GST tag N-Terminus)

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Recombinant Human Neurogenin 2/NGN2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

ATOH4, BHLHA8, NGN2, NEUROG2, Neurogenin-2, NGN-2, Class A basic helix-loop-helix protein 8, Protein atonal homolog 4, bHLHa8

1 Images
SDS-PAGE - Recombinant Human Neurogenin 2/NGN2 protein (GST tag N-Terminus) (AB131781)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Neurogenin 2/NGN2 protein (GST tag N-Terminus) (AB131781)

12.5% SDS-PAGE analysis of ab131781 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

Q9H2A3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Cell Lines & Lysates

AB94116

Neurogenin 2 overexpression 293T lysate (whole cell)

Western blot - Neurogenin 2 overexpression 293T lysate (whole cell) (AB94116)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Neurogenin 2
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Sequence info

[{"sequence":"MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI","proteinLength":"Full Length","predictedMolecularWeight":"55 kDa","actualMolecularWeight":null,"aminoAcidEnd":272,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9H2A3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurogenin 2 also known as NGN2 is a basic helix-loop-helix (bHLH) transcription factor. This protein weighs about 28 kDa and is found mostly in the developing central nervous system. It plays a role in the specification of neuronal lineages. Neurogenin controls the differentiation of neural progenitor cells into neurons by activating neuron-specific genes. NGN2 expression is marked in the embryonic cortex spinal cord and dorsal root ganglia.
Biological function summary

Neurogenin 2 functions as a master regulator for neuronal differentiation. It facilitates the conversion of neuroepithelial cells into neurons and is part of a transcriptional complex that includes related proteins like NeuroD. As it promotes neuron fate NGN2 partners with transcription machinery to activate neuronal gene expression. This activity shapes brain regions by directing diverse neuronal identities especially in areas critical for sensory processing.

Pathways

Several key signaling cascades involve Neurogenin 2 in neuronal development. The Notch signaling pathway is important with NGN2 directly antagonizing the effects of Hes1 a Notch target. Additionally the Wnt signaling pathway is important where NGN2 interacts with β-catenin to further regulate neural differentiation. These pathways ensure the precise coordination of neuron formation influenced by NGN2's activity alongside other essential proteins like ASCL1.

Aberrant expression or function of Neurogenin 2 associates with certain neurological conditions. One notable disorder is autism spectrum disorder (ASD) where proper neuronal circuitry under construction fails. NGN2's misregulation is also linked to neurodegenerative diseases such as Alzheimer's disease where neurons fail to maintain their identity and function. In these contexts NGN2's interaction with other transcription factors like Rest contributes to disease pathology highlighting its significant role in brain health.
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Specifications

Form

Liquid

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General info

Function

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
See full target information NEUROG2
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Product promise

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For full details, please see our Terms & Conditions

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