Recombinant Human Neuromedin B protein (denatured) (His tag N-Terminus)
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Recombinant Human Neuromedin B protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 25 to 121 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
Neuromedin-B, NMB
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Neuromedin B protein (denatured) (His tag N-Terminus) (AB167850)
15% SDS-PAGE analysis of 3µg ab167850.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Neuromedin B influences several physiological functions such as regulation of smooth muscle contraction thermoregulation and the release of anterior pituitary hormones. It plays a role in the modulation of circadian rhythms and feeding behavior. Neuromedin B is not typically part of a complex but its biological activity is strongly dependent on its interaction with its specific receptor NMBR. The peptide-receptor interaction activates downstream signaling pathways that mediate its effects.
Pathways
Several important biological pathways involve neuromedin B. One of these pathways is the G-protein signaling pathway which influences neurotransmission and hormone release. Neuromedin B affects this process through its receptor-mediated activation of G-proteins. Another important pathway is the MAPK/ERK pathway where neuromedin B through NMBR participates in cell growth and survival processes. Neuromedin B is related to proteins such as gastrin-releasing peptide (GRP) that also belongs to the bombesin-like family sharing similarities in receptor interaction and signaling functions.
Specifications
Form
Liquid
General info
Function
Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed : 31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
Sequence similarities
Belongs to the bombesin/neuromedin-B/ranatensin family.
Target data
Complementary Products
Product promise
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