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Recombinant human Neuropilin 1 protein (Fc Chimera Active) is a Human Full Length protein, in the 22 to 644 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Alternative names=Neuropilin-1, Vascular endothelial cell growth factor 165 receptor, NRP, NRP1, VEGF165R
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
Tag free
SDS-PAGE, FuncS
Yes
F R N D K C G D T I K I E S P G Y L T S P G Y P H S Y H P
S E K C E W L I Q A P D P Y Q R I M I N F N P H F D L E D R D C K Y D Y V E V F D G E N E N G H F R
G K F C G K I A P P P V V S S G P F L F I K F V S D Y E T H G A G F S I R Y E I F K R G P E C S Q N
Y T T P S G V I K S P G F P E K Y P N S L E C T Y I V F V P K M S E I I L E F E S F D L E P D S N P
P G G M F C R Y D R L E I W D G F P D V G P H I G R Y C G Q K T P G R I R S S S G I L S M V F Y T D
S A I A K E G F S A N Y S V L Q S S V S E D F K C M E A L G M E S G E I H S D Q I T A S S Q Y S T N
W S A E R S R L N Y P E N G W T P G E D S Y R E W I Q V D L G L L R F V T A V G T Q G A I S K E T K
K K Y Y V K T Y K I D V S S N G E D W I T I K E G N K P V L F Q G N T N P T D V V V A V F P K P L I
T R F V R I K P A T W E T G I S M R F E V Y G C K I T D Y P C S G M L G M V S G L I S D S Q I T S S
N Q G D R N W M P E N I R L V T S R S G W A L P P A P H S Y I N E W L Q I D L G E E K I V R G I I I
Q G G K H R E N K V F M R K F K I G Y S N N G S D W K M I M D D S K R K A K S F E G N N N Y D T P E
L R T F P A L S T R F I R I Y P E R A T H G G L G L R M E L L G C E V E A P T A G P T T P N G N L V
D E C D D D Q A N C H S G T G D D F Q L T G G T T V L A T E K P T V I D S T I Q S G I K
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Recombinant human Neuropilin 1 protein (Fc Chimera Active) is a Human Full Length protein, in the 22 to 644 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Alternative names=Neuropilin-1, Vascular endothelial cell growth factor 165 receptor, NRP, NRP1, VEGF165R
>95% SDS-PAGE
< 1 EU/µg
HEK 293 cells
Tag free
SDS-PAGE, FuncS
Yes
Measured by its binding ability in a functional ELISA. Immobilized ab221023 at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF165 with a linear range of 5-40 ng/mL.
96.5 kDa
22 to 644
F R N D K C G D T I K I E S P G Y L T S P G Y P H S Y H P
S E K C E W L I Q A P D P Y Q R I M I N F N P H F D L E D R D C K Y D Y V E V F D G E N E N G H F R
G K F C G K I A P P P V V S S G P F L F I K F V S D Y E T H G A G F S I R Y E I F K R G P E C S Q N
Y T T P S G V I K S P G F P E K Y P N S L E C T Y I V F V P K M S E I I L E F E S F D L E P D S N P
P G G M F C R Y D R L E I W D G F P D V G P H I G R Y C G Q K T P G R I R S S S G I L S M V F Y T D
S A I A K E G F S A N Y S V L Q S S V S E D F K C M E A L G M E S G E I H S D Q I T A S S Q Y S T N
W S A E R S R L N Y P E N G W T P G E D S Y R E W I Q V D L G L L R F V T A V G T Q G A I S K E T K
K K Y Y V K T Y K I D V S S N G E D W I T I K E G N K P V L F Q G N T N P T D V V V A V F P K P L I
T R F V R I K P A T W E T G I S M R F E V Y G C K I T D Y P C S G M L G M V S G L I S D S Q I T S S
N Q G D R N W M P E N I R L V T S R S G W A L P P A P H S Y I N E W L Q I D L G E E K I V R G I I I
Q G G K H R E N K V F M R K F K I G Y S N N G S D W K M I M D D S K R K A K S F E G N N N Y D T P E
L R T F P A L S T R F I R I Y P E R A T H G G L G L R M E L L G C E V E A P T A G P T T P N G N L V
D E C D D D Q A N C H S G T G D D F Q L T G G T T V L A T E K P T V I D S T I Q S G I K
Full Length
No
Recombinant
Human
Reconstitute with sterile deionized water to a concentration of 200 µg/ml.
pH: 7.4
Constituents: L-Arginine, Sodium chloride, 5% Trehalose, 0.75% Glycine, 0.61% Tris
Lyophilized
Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).
Belongs to the neuropilin family.
Mitochondrion membrane
Blue Ice
-20°C
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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