Recombinant Human Neurotensin protein (His tag) is a Human Full Length protein, in the 24 to 148 aa range, expressed in Baculovirus infected insect, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>90% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
Baculovirus infected insect cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
A D P S D S E E E M K A L E A D F L T N M H T S K I S K A H V P S W K M T L L N V C S L V N N L N S P A E E T G E V H E E E L V A R R K L P T A L D G F S L E A M L T I Y Q L H K I C H S R A F Q H W E L I Q E D I L D T G N D K N G K E E V I K R K I P Y I L H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Alternative names
Neurotensin/neuromedin N, NTS
Recommended products
Recombinant Human Neurotensin protein (His tag) is a Human Full Length protein, in the 24 to 148 aa range, expressed in Baculovirus infected insect, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Alternative names
Neurotensin/neuromedin N, NTS
Key facts
- Purity
>90% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
Baculovirus infected insect cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- P30990-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: PBS, 10% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
A D P S D S E E E M K A L E A D F L T N M H T S K I S K A H V P S W K M T L L N V C S L V N N L N S P A E E T G E V H E E E L V A R R K L P T A L D G F S L E A M L T I Y Q L H K I C H S R A F Q H W E L I Q E D I L D T G N D K N G K E E V I K R K I P Y I L H H H H H H
- Accession
- Protein length
Full Length
- Predicted molecular weight
15.4 kDa
- Amino acids
24 to 148
- Nature
Recombinant
- Tags
His tag C-Terminus
Specifications
- Form
Liquid
- Additional notes
Affinity purified
General info
- Function
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
- Sequence similarities
Belongs to the neurotensin family.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Neurotensin also known by the abbreviation NT is a peptide neurotransmitter that consists of 13 amino acids giving it a relatively modest mass. It is well-known under the name NTS and is mainly expressed in the central nervous system especially within the hypothalamus midbrain and also found in peripheral tissues like the gastrointestinal tract. Neurotensin acts by binding to specific G-protein-coupled receptors such as NTSR1 to mediate its effects.
- Biological function summary
The peptide neurotransmitter exhibits various functions in both the central and peripheral nervous systems. It can act as a neuromodulator affecting dopamine signaling and impacts the regulation of pain temperature and even food intake. Neurotensin forms part of complexes with other neurotransmitters and interacts closely with pathways related to dopamine suggesting a significant influence on mood and cognition.
- Pathways
The interaction of neurotensin with dopamine pathways is particularly important. It plays a role in modulating the dopaminergic signaling cascades that involve receptor proteins like D2 dopamine receptors. Additionally neurotensin impacts the acute-phase response pathway altering the signaling dynamics in inflammation and immune response.
- Associated diseases and disorders
Neurotensin has connections to conditions such as schizophrenia and obesity. Its modulation of dopamine pathways links it to schizophrenia where altered dopamine signaling is evident with potential involvement of proteins like NTSR1 and D2 receptors. Additionally because neurotensin influences food intake and energy balance it relates to obesity with its effects mediated through interactions with other gut-derived peptides and receptors including ghrelin and leptin receptors.
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1 product image
SDS-PAGE - Recombinant Human Neurotensin protein (His tag) (ab224777)
15% SDS-PAGE analysis of 3 μg ab224777.
MW: 13.5-18 kDa (SDS-PAGE under reducing conditions).
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