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AB9840

Recombinant Human Neurturin protein

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Recombinant Human Neurturin protein is a Human Full Length protein, expressed in Escherichia coli, with >98%, suitable for SDS-PAGE, FuncS.

View Alternative Names

Neurturin, NRTN

Key facts

Purity

>98% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, FuncS

applications

Biologically active

No

Accession

Q99748

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water to a concentration of 0.1mg/ml

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Human Neurturin is fully biologically active when compared to standards. Human Neurturin at a concentration of 100ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"22 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q99748","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurturin also called NRTN is a neurotrophic factor belonging to the glial cell line-derived neurotrophic factor (GDNF) family. It is a protein weighing approximately 23 kDa. Neurturin promotes the survival of neurons and is mainly active in the central nervous system and peripheral nervous system. It is expressed in various tissues including the brain spinal cord and organs such as the liver and pancreas.
Biological function summary

Neurturin supports the maintenance and function of many neuronal populations. It partners with the RET receptor tyrosine kinase and the GFRα2 co-receptor to form a receptor complex that mediates its signaling. This interaction is important for neuronal differentiation and survival especially in dopamine-producing neurons and parasympathetic neurons. Neurturin's activity ensures proper nerve development and the maintenance of effective neuronal networks.

Pathways

Several important elements are involved with neurturin function. It plays a role in the MAPK/ERK and the PI3K/Akt signaling pathways both of which are essential for cell survival and growth. In these pathways neurturin acts alongside proteins like GDNF and RET helping to transmit cellular signals that either promote cell survival or modulate neuronal function depending upon the cellular context.

Research links neurturin to conditions like Parkinson’s disease and Hirschsprung's disease. In Parkinson’s disease the decrease in dopaminergic neurons correlates with malfunction or decreased activity of neurturin and its associated receptors like RET. Similarly insufficient signaling involving neurturin and its receptor complex might contribute to the development of Hirschsprung's disease a disorder related to the absence of nerve cells in the colon.
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Specifications

Form

Lyophilized

Additional notes

Sterile filtered Greater than 98% pure by HPLC analyses. Endotoxin level is less than 0.1 ng per g (1EU/g).

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General info

Function

Growth factor that supports the survival of sympathetic neurons in culture (PubMed : 8945474). May regulate the development and maintenance of the CNS (PubMed : 8945474). Involved in the development of the neural crest (PubMed : 15242795). Might control the size of non-neuronal cell population such as haemopoietic cells (PubMed : 8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (PubMed : 10829012, PubMed : 29414779, PubMed : 31535977). Heparan sulfate-binding is required for signaling (PubMed : 29414779).

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

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Product protocols

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Target data

Growth factor that supports the survival of sympathetic neurons in culture (PubMed : 8945474). May regulate the development and maintenance of the CNS (PubMed : 8945474). Involved in the development of the neural crest (PubMed : 15242795). Might control the size of non-neuronal cell population such as haemopoietic cells (PubMed : 8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (PubMed : 10829012, PubMed : 29414779, PubMed : 31535977). Heparan sulfate-binding is required for signaling (PubMed : 29414779).
See full target information NRTN
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