Recombinant Human NHE-6 protein

Specifications

Form

Liquid

General info

Function

Endosomal Na(+), K(+)/H(+) antiporter (PubMed : 15522866, PubMed : 28635961, PubMed : 31676550, PubMed : 32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed : 15522866, PubMed : 28635961, PubMed : 31676550, PubMed : 32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed : 20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).

Sequence similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Post-translational modifications

Ubiquitinated (in vitro).. Glycosylated.

Subcellular localisation

Endosome membrane