Recombinant Human NHE-6 protein is a Human Full Length protein, in the 1 to 701 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Publications
Filter by
- Translational psychiatry 13:342023Altered distribution and localization of organellar Na/H exchangers in postmortem schizophrenia dorsolateral prefrontal cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBrandon S Pruett,Anita L Pinner,Pitna Kim,James H Meador-WoodruffPubMed 36732328
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A R R G W R R A P L R R G V G S S P R A R R L M R P L W L L L A V G V F D W A G A S D G G G G E A R A M D E E I V S E K Q A E E S H R Q D S A N L L I F I L L L T L T I L T I W L F K H R R A R F L H E T G L A M I Y G L L V G L V L R Y G I H V P S D V N N V T L S C E V Q S S P T T L L V N V S G K F Y E Y M L K G E I S S H E L N N V Q D N E M L R K V T F D P E V F F N I L L P P I I F Y A G Y S L K R R H F F R N L G S I L A Y A F L G T A I S C F V I G S I M Y G C V T L M K V T G Q L A G D F Y F T D C L L F G A I V S A T D P V T V L A I F H E L Q V D V E L Y A L L F G E S V L N D A V A I V L S S S I V A Y Q P A G D N S H T F D V T A M F K S I G I F L G I F S G S F A M G A A T G V V T A L V T K F T K L R E F Q L L E T G L F F L M S W S T F L L A E A W G F T G V V A V L F C G I T Q A H Y T Y N N L S T E S Q H R T K Q L F E L L N F L A E N F I F S Y M G L T L F T F Q N H V F N P T F V V G A F V A I F L G R A A N I Y P L S L L L N L G R R S K I G S N F Q H M M M F A G L R G A M A F A L A I R D T A T Y A R Q M M F S T T L L I V F F T V W V F G G G T T A M L S C L H I R V G V D S D Q E H L G V P E N E R R T T K A E S A W L F R M W Y N F D H N Y L K P L L T H S G P P L T T T L P A C C G P I A R C L T S P Q A Y E N Q E Q L K D D D S D L I L N D G D I S L T Y G D S T V N T E P A T S S A P R R F M G N S S E D A L D R E L A F G D H E L V I R G T R L V L P M D D S E P P L N L L D N T R H G P A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).
Alternative names
KIAA0267, NHE6, SLC9A6, Sodium/hydrogen exchanger 6, Na(+)/H(+) exchanger 6, Solute carrier family 9 member 6, NHE-6
Recommended products
Recombinant Human NHE-6 protein is a Human Full Length protein, in the 1 to 701 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q92581-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A R R G W R R A P L R R G V G S S P R A R R L M R P L W L L L A V G V F D W A G A S D G G G G E A R A M D E E I V S E K Q A E E S H R Q D S A N L L I F I L L L T L T I L T I W L F K H R R A R F L H E T G L A M I Y G L L V G L V L R Y G I H V P S D V N N V T L S C E V Q S S P T T L L V N V S G K F Y E Y M L K G E I S S H E L N N V Q D N E M L R K V T F D P E V F F N I L L P P I I F Y A G Y S L K R R H F F R N L G S I L A Y A F L G T A I S C F V I G S I M Y G C V T L M K V T G Q L A G D F Y F T D C L L F G A I V S A T D P V T V L A I F H E L Q V D V E L Y A L L F G E S V L N D A V A I V L S S S I V A Y Q P A G D N S H T F D V T A M F K S I G I F L G I F S G S F A M G A A T G V V T A L V T K F T K L R E F Q L L E T G L F F L M S W S T F L L A E A W G F T G V V A V L F C G I T Q A H Y T Y N N L S T E S Q H R T K Q L F E L L N F L A E N F I F S Y M G L T L F T F Q N H V F N P T F V V G A F V A I F L G R A A N I Y P L S L L L N L G R R S K I G S N F Q H M M M F A G L R G A M A F A L A I R D T A T Y A R Q M M F S T T L L I V F F T V W V F G G G T T A M L S C L H I R V G V D S D Q E H L G V P E N E R R T T K A E S A W L F R M W Y N F D H N Y L K P L L T H S G P P L T T T L P A C C G P I A R C L T S P Q A Y E N Q E Q L K D D D S D L I L N D G D I S L T Y G D S T V N T E P A T S S A P R R F M G N S S E D A L D R E L A F G D H E L V I R G T R L V L P M D D S E P P L N L L D N T R H G P A
- Accession
- Q92581
- Protein length
- Full Length
- Amino acids
- 1 to 701
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).
- Sequence similarities
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
- Post-translational modifications
Ubiquitinated (in vitro).
- Subcellular localisation
- Endosome membrane, Recycling endosome membrane
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as SLC9A6.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human NHE-6 protein (ab161011)
ab161011 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com