Recombinant Human NHP2 protein (His tag) is a Human Full Length protein, in the 1 to 153 aa range, expressed in Escherichia coli, with >95% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
M G S S H H H H H H S S G L V P R G S H M T K I K A D P D G P E A Q A E A C S G E R T Y Q E L L V N Q N P I A Q P L A S R R L T R K L Y K C I K K A V K Q K Q I R R G V K E V Q K F V N K G E K G I M V L A G D T L P I E V Y C H L P V M C E D R N L P Y V Y I P S K T D L G A A A G S K R P T C V I M V K P H E E Y Q E A Y D E C L E E V Q S L P L P L
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
NOLA2, HSPC286, NHP2, H/ACA ribonucleoprotein complex subunit 2, Nucleolar protein family A member 2, snoRNP protein NHP2
Recombinant Human NHP2 protein (His tag) is a Human Full Length protein, in the 1 to 153 aa range, expressed in Escherichia coli, with >95% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 8
Constituents: 0.58% Sodium chloride, 0.24% Tris, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Belongs to the eukaryotic ribosomal protein eL8 family.
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