Recombinant Human Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Nicotinic Acetylcholine Receptor alpha 5 (CHRNA5) also known as the nicotinic receptor plays a mechanical role as part of the heteromeric nicotinic acetylcholine receptor (nAChR) complex. It is a subunit that contributes to the formation of ligand-gated ion channels sensitive to acetylcholine a neurotransmitter. The receptor's mass varies depending on the specific subunit composition but is generally around 55 kDa. CHRNA5 expression occurs mainly in the central nervous system including areas like the brain and spinal cord and it also shows expression in some peripheral tissues.

Biological function summary

The Nicotinic Acetylcholine Receptor alpha 5 modulates neural signaling by affecting the flow of ions through its channel which is activated upon acetylcholine binding. It is part of a complex that includes other nicotinic acetylcholine receptor subunits forming a transmembrane channel. This receptor complex adjusts neurotransmission dynamics and influences synaptic plasticity. It plays roles in cognitive processes and behavioral regulation through its modulation of cholinergic signaling pathways.

Pathways

The Nicotinic Acetylcholine Receptor alpha 5 influences neural signaling through involvement in the cholinergic and dopamine pathways. It interacts with proteins like CHRNA4 and CHRNB2 integral components of these pathways where it modulates synaptic activity and neurotransmission. The receptor's function impacts neurotransmitter release which is critical for processing cognitive and reward-related signals in the brain.

The Nicotinic Acetylcholine Receptor alpha 5 has links to nicotine addiction and schizophrenia. Genetic variations in CHRNA5 are associated with increased risk for nicotine dependence suggesting its role in addiction pathways. Studies implicate it in schizophrenia where its altered expression or function might affect dopaminergic signaling balance. The receptor's association with proteins like CHRNA4 highlights its involvement in disorders through complex interactions in neural transmission.