Recombinant Human Nicotinic Acetylcholine Receptor beta 2/CHRNB2 protein is a Human Fragment protein, in the 26 to 130 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
Amino acid sequence
T D T E E R L V E H L L D P S R Y N K L I R P A T N G S E L V T V Q L M V S L A Q L I S V H E R E Q I M T T N V W L T Q E W E D Y R L T W K P E E F D N M K K V R L P S K H I W L P D V V L Y N N A D G M Y E V S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Alternative names
Neuronal acetylcholine receptor subunit beta-2, CHRNB2
Recommended products
Recombinant Human Nicotinic Acetylcholine Receptor beta 2/CHRNB2 protein is a Human Fragment protein, in the 26 to 130 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Alternative names
Neuronal acetylcholine receptor subunit beta-2, CHRNB2
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
- Accession
- P17787-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
T D T E E R L V E H L L D P S R Y N K L I R P A T N G S E L V T V Q L M V S L A Q L I S V H E R E Q I M T T N V W L T Q E W E D Y R L T W K P E E F D N M K K V R L P S K H I W L P D V V L Y N N A D G M Y E V S
- Accession
- Protein length
Fragment
- Amino acids
26 to 130
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
- Sequence similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
This product was previously labelled as Nicotinic Acetylcholine Receptor beta 2.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Nicotinic Acetylcholine Receptor beta 2 (CHRNB2) also known as nAChR beta-2 subunit is an integral membrane protein involved in forming ligand-gated ion channels. It has a pivotal role in neurotransmission by responding to the neurotransmitter acetylcholine. CHRNB2 typically forms heteromeric complexes with alpha subunits to yield functional receptors. It is highly expressed in the central nervous system including regions such as the cerebral cortex and hippocampus. Each beta-2 subunit has a molecular mass of approximately 50 kDa.
- Biological function summary
CHRNB2 influences synaptic plasticity and cognitive processes. It functions as part of a pentameric receptor complex usually composed of various subunits that determine the receptor's physiological properties. The receptor modulates neurotransmitter release and impacts neuronal excitability. Its activity contributes to cognitive functions such as attention learning and memory mediated through ion flow across cell membranes that affect neuron firing rates.
- Pathways
The beta-2 subunit of the nicotinic acetylcholine receptor is integral to the cholinergic pathway. It interacts with the dopaminergic system by modulating dopaminergic neuron activity and dopamine release. This interaction plays a significant role in pathways related to reward pleasure and addiction. Proteins such as the dopamine transporter (DAT) are closely linked within these pathways affecting the dynamics of neurotransmitter availability and receptor activation.
- Associated diseases and disorders
Alterations in CHRNB2 function associate with neurological disorders like nicotine addiction and Alzheimer's disease. Dysfunctional receptors due to mutations can disrupt cognitive function and behavior highlighting their role in Alzheimer's pathology where neuronal communication is impaired. Other proteins such as amyloid precursor protein (APP) link CHRNB2 to the disease process by influencing neurodegenerative outcomes and synaptic maintenance.
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1 product image
SDS-PAGE - Recombinant Human Nicotinic Acetylcholine Receptor beta 2/CHRNB2 protein (ab152280)
ab152280 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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